Cai Xiaoli, Jin Ming, Yao Longfukang, He Bin, Ahmed Saeed, Safdar Waseem, Ahmad Ijaz, Cheng Dong-Bing, Lei Zhixin, Sun Taolei
School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
J Mater Chem B. 2023 Jan 25;11(4):716-733. doi: 10.1039/d2tb02001g.
As a promising delivery nanosystem for drug controlled-release, nanocarriers (NCs) have been investigated widely. Although various studies have concentrated on the preparation and characterization of nanoparticles (NPs), clinical applications are rarely reported, due to the unclear distribution, absorption, metabolism, toxicology processes and drug release mechanism. The clinical application of NCs is therefore still a long way off. This review describes the effects of the properties of NCs (including size, shape, surface properties, porosity, elasticity and so on) on pharmacological and toxicological behaviours and medical applications. Moreover, this study is intended to help the readers understand the behaviours and mechanisms of NCs and positively face the challenges caused by the variety of complicated and limited processes of NCs . Importantly, this article provides some strategies for the clinical application of NCs and may provide ideas to enhance the therapeutic efficacy of NCs without increasing the toxicology, by introducing tracing technology, which can be more suitable in contributing to the development of safety and efficacy of NCs and the growth of nanotechnology.
作为一种很有前景的药物控释纳米递送系统，纳米载体（NCs）已得到广泛研究。尽管各种研究都集中在纳米颗粒（NPs）的制备和表征上，但由于其分布、吸收、代谢、毒理学过程及药物释放机制尚不清楚，临床应用报道很少。因此，NCs的临床应用仍有很长的路要走。本综述描述了NCs的性质（包括大小、形状、表面性质、孔隙率、弹性等）对药理和毒理行为以及医学应用的影响。此外，本研究旨在帮助读者了解NCs的行为和机制，并积极面对由NCs各种复杂且有限的过程所带来的挑战。重要的是，本文提供了一些NCs临床应用的策略，并可能通过引入追踪技术提供思路，在不增加毒理学的情况下提高NCs的治疗效果，这可能更有助于NCs安全性和有效性的发展以及纳米技术的进步。
