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2022 年德国脊柱学会(DWG)Georg Schmorl 奖:骨质疏松性胸腰椎骨折住院患者的当前治疗方法——EOFTT 研究结果。

Georg Schmorl prize of the German spine society (DWG) 2022: current treatment for inpatients with osteoporotic thoracolumbar fractures-results of the EOFTT study.

机构信息

Department of Trauma and Reconstructive Surgery, BG Klinikum Bergmannstrost Halle gGmbH, 06112, Halle, Germany.

Department of Trauma Hand and Reconstructive Surgery, University Hospital Jena, Jena, Germany.

出版信息

Eur Spine J. 2023 May;32(5):1525-1535. doi: 10.1007/s00586-022-07519-x. Epub 2023 Jan 3.

Abstract

AIM

Osteoporotic thoracolumbar fractures are of increasing importance. To identify the optimal treatment strategy this multicentre prospective cohort study was performed.

PURPOSE

Patients suffering from osteoporotic thoracolumbar fractures were included. Excluded were tumour diseases, infections and limb fractures. Age, sex, trauma mechanism, OF classification, OF-score, treatment strategy, pain condition and mobilization were analysed.

METHODS

A total of 518 patients' aged 75 ± 10 (41-97) years were included in 17 centre. A total of 174 patients were treated conservatively, and 344 were treated surgically, of whom 310 (90%) received minimally invasive treatment. An increase in the OF classification was associated with an increase in both the likelihood of surgery and the surgical invasiveness.

RESULTS

Five (3%) complications occurred during conservative treatment, and 46 (13%) occurred in the surgically treated patients. 4 surgical site infections and 2 mechanical failures requested revision surgery. At discharge pain improved significantly from a visual analogue scale score of 7.7 (surgical) and 6.0 (conservative) to a score of 4 in both groups (p < 0.001). Over the course of treatment, mobility improved significantly (p = 0.001), with a significantly stronger (p = 0.007) improvement in the surgically treated patients.

CONCLUSION

Fracture severity according to the OF classification is significantly correlated with higher surgery rates and higher invasiveness of surgery. The most commonly used surgical strategy was minimally invasive short-segmental hybrid stabilization followed by kyphoplasty/vertebroplasty. Despite the worse clinical conditions of the surgically treated patients both conservative and surgical treatment led to an improved pain situation and mobility during the inpatient stay to nearly the same level for both treatments.

摘要

目的

骨质疏松性胸腰椎骨折的重要性日益增加。为了确定最佳的治疗策略,进行了这项多中心前瞻性队列研究。

目的

纳入患有骨质疏松性胸腰椎骨折的患者。排除肿瘤疾病、感染和肢体骨折。分析年龄、性别、创伤机制、OF 分类、OF 评分、治疗策略、疼痛状况和活动度。

方法

共纳入 17 个中心的 518 名年龄 75±10(41-97)岁的患者。共 174 例患者接受保守治疗,344 例患者接受手术治疗,其中 310 例(90%)接受微创治疗。OF 分类的增加与手术的可能性和手术的侵袭性增加有关。

结果

保守治疗中发生 5 例(3%)并发症,手术治疗中发生 46 例(13%)并发症。4 例手术部位感染和 2 例机械故障需要翻修手术。出院时,两组疼痛均明显改善,从视觉模拟评分(VAS)7.7(手术)和 6.0(保守)降至 4(均p<0.001)。在治疗过程中,活动度明显改善(p=0.001),手术治疗患者的改善更为显著(p=0.007)。

结论

根据 OF 分类的骨折严重程度与较高的手术率和手术侵袭性显著相关。最常用的手术策略是微创短节段混合稳定,其次是后凸成形术/椎体成形术。尽管手术治疗患者的临床状况较差,但保守和手术治疗都能显著改善疼痛状况和住院期间的活动度,两种治疗方法的效果几乎相同。

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