器官形成期给大鼠施用偏钒酸钠的胚胎毒性作用。
Embryotoxic effects of sodium metavanadate administered to rats during organogenesis.
作者信息
Paternain J L, Domingo J L, Llobet J M, Corbella J
机构信息
Departamento de Bioquímica, Facultad de Medicina, Universidad de Barcelona, Reus/Tarragona, Spain.
出版信息
Rev Esp Fisiol. 1987 Jun;43(2):223-7.
PMID:3659548
Abstract
Pregnant Sprague-Dawley rats were given orally a daily dose of 0, 5, 10 or 20 mg NaVO3/kg from the sixth through the fourteenth day of pregnancy. Fetal examinations were performed on day 20 of gestation. Sodium metavanadate was neither embryolethal nor teratogenic in rats when administered orally at 20 mg/kg/day or lower. Nevertheless, this dose was embryotoxic.
摘要
在妊娠第6天至第14天，给怀孕的斯普拉格-道利大鼠每日经口给予0、5、10或20毫克偏钒酸钠/千克的剂量。在妊娠第20天进行胎儿检查。当以20毫克/千克/天或更低剂量经口给予大鼠时，偏钒酸钠对大鼠既无胚胎致死性也无致畸性。然而，该剂量具有胚胎毒性。
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