Department of Orthopedics, the First People's Hospital of Jiashan, Zhejiang Province, China.
Medicine (Baltimore). 2022 Dec 30;101(52):e32315. doi: 10.1097/MD.0000000000032315.
Parkinson's disease (PD) patients have been shown to have various musculoskeletal problems, the postoperative outcomes of total knee arthroplasty procedure might be less predictable if performed on a patient who has PD. We conducted a protocol for systematic review and meta-analysis to evaluate the functional outcomes, activity levels, mortalities, implant survival rates, and complications of total knee arthroplasty in patients with PD.
This study follows the guideline of the preferred reporting items for systematic reviews and meta-analyses protocols and has been registered on the International Prospective Register of Systematic Reviews with CRD42022375885. Two independent reviewers will search for databases including PubMed, Embase, Cochrane Library website, ClinicalTrials.gov databases, Chinese National Knowledge Infrastructure Database, Wanfang database, and VIP database using the search strategies recommended by the Cochrane Back Review Group. The RevMan 5.3 software (Cochrane Collaboration, Oxford, UK) will be used to conduct the meta-analyses.
The results of this systematic review will be published in a peer-reviewed journal.
This study may provide evidence for the clinical application of total knee arthroplasty in patients with PD.
帕金森病（PD）患者存在各种肌肉骨骼问题，如果对 PD 患者进行全膝关节置换术，其术后结果可能难以预测。我们制定了一项系统评价和荟萃分析方案，以评估 PD 患者全膝关节置换术的功能结果、活动水平、死亡率、假体生存率和并发症。
本研究遵循系统评价和荟萃分析方案的首选报告项目指南，并已在国际前瞻性注册系统评价注册，注册号为 CRD42022375885。两名独立评审员将使用 Cochrane 背部综述组推荐的搜索策略，在包括 PubMed、Embase、 Cochrane 图书馆网站、ClinicalTrials.gov 数据库、中国国家知识基础设施数据库、万方数据库和 VIP 数据库在内的数据库中进行搜索。RevMan 5.3 软件（Cochrane 协作，英国牛津）将用于进行荟萃分析。
本系统评价的结果将发表在同行评议的期刊上。
本研究可为 PD 患者全膝关节置换术的临床应用提供证据。
