Department of General Surgery, Yuhuan Second People's Hospital, Zhejiang, China.
Department of Radiology, Yuhuan Second People's Hospital, Zhejiang, China.
Medicine (Baltimore). 2023 Feb 3;102(5):e32858. doi: 10.1097/MD.0000000000032858.
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors. Surgical treatment has made great progress in CRC liver metastasis (CRLM), including radiofrequency ablation (RFA), and hepatectomy. We perform a protocol for systematic review and meta-analysis to compare the efficacy and safety of ultrasound-guided RFA and hepatectomy in treating CRLM.
This systematic review protocol will be reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analyses Protocols (PRISMA-P) 2015 Statement. The protocol has been registered in PROSPERO (CRD42022371561). PubMed, EMBASE, MEDLINE, the Cochrane Library, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang Database, ClinicalTrials.gov trials registry, and Chinese Clinical Trial Registry will be searched from January 1980 to December 2022. Only randomized controlled trials will be included. Cochrane systematic evaluation tool is used to assess the risk of bias. The RevMan 5.3 software (Cochrane Collaboration, Oxford, UK) will be applied to conduct the meta-analyses.
The results of this systematic review and meta-analysis will be publicly available and published in a peer-reviewed journal.
This study may provide more convincing evidence to help surgeons make decisions when dealing with CRLM.
结直肠癌（CRC）是最常见的恶性肿瘤之一。CRC 肝转移（CRLM）的外科治疗取得了很大进展，包括射频消融（RFA）和肝切除术。我们制定了一个系统评价和荟萃分析的方案，以比较超声引导下 RFA 和肝切除术治疗 CRLM 的疗效和安全性。
本系统评价方案将按照 Preferred Reporting Items for Systematic Review and Meta-Analyses Protocols（PRISMA-P）2015 声明进行报告。该方案已在 PROSPERO（CRD42022371561）中注册。我们将从 1980 年 1 月至 2022 年 12 月检索 PubMed、EMBASE、MEDLINE、Cochrane 图书馆、中国国家知识基础设施、中国生物医学文献数据库、万方数据库、ClinicalTrials.gov 试验注册库和中国临床试验注册库。仅纳入随机对照试验。使用 Cochrane 系统评价工具评估偏倚风险。RevMan 5.3 软件（Cochrane 协作网，英国牛津）将用于进行荟萃分析。
本系统评价和荟萃分析的结果将公开，并发表在同行评议的期刊上。
本研究可能为外科医生在处理 CRLM 时做出决策提供更有说服力的证据。
