Department of Gastroenterology, Centro Hospitalar Tondela-Viseu, E.P.E., Viseu, Portugal.
Medicine (Baltimore). 2022 Dec 30;101(52):e32279. doi: 10.1097/MD.0000000000032279.
Patients with Inflammatory Bowel Disease (IBD) are at increased risk of psychological and physical burden, including sexual dysfunction (SD). This study aimed to assess the prevalence of SD and to identify its predictive factors, in IBD patients. This unicentric cross-sectional case-control survey (ratio 2:1) included patients followed at the day hospital IBD consultation, in the Gastroenterology department of a tertiary referral center, for 2 years. Participants received anonymous questionnaires, concerning basic characteristics and sexual function, and a questionnaire on anxiety and depression, body image, fatigue, and IBD-specific health-related quality of life (QoL). We analyzed data from 120 IBD patients and 60 healthy controls. Forty-two female (56.8%) and 6 male (14.6%) IBD patients, and 6 women (15%) and 2 males (10%) of the control group presented SD. SD was significantly higher in IBD patients with age between 18 and 30 and 51 and 60 than in healthy controls (P < .05) Regarding multivariate analysis, age was a predictive factor for SD in males (P = .014), and anxiety and depression (P = .002) and fatigue (P = .043) in females. SD is a predictor of lower QoL among IBD patients, considering the last 15 (P < .001) and 60 days (P = .001), regarding univariate analysis. SD (P = .007), body image distortion (P < .001), and fatigue (P = .004) were predictors of low QoL (last 15 days, multivariate analysis). SD was more prevalent in IBD patients than in the control group and impacted negatively the QoL of patients. Age was a predictive factor for SD in men while anxiety and depression, and fatigue were predictive of SD in women.
炎症性肠病（IBD）患者存在心理和身体负担增加的风险，包括性功能障碍（SD）。本研究旨在评估 IBD 患者 SD 的患病率，并确定其预测因素。这项单中心横断面病例对照研究（比例为 2:1）纳入了在三级转诊中心胃肠病科日间病房接受 2 年随访的 IBD 患者。参与者接受了关于基本特征和性功能的匿名问卷，以及关于焦虑和抑郁、身体形象、疲劳和 IBD 特异性健康相关生活质量（QoL）的问卷。我们分析了 120 名 IBD 患者和 60 名健康对照者的数据。42 名女性（56.8%）和 6 名男性（14.6%）IBD 患者，以及对照组中的 6 名女性（15%）和 2 名男性（10%）存在 SD。与健康对照组相比，年龄在 18-30 岁和 51-60 岁之间的 IBD 患者的 SD 明显更高（P <.05）。关于多变量分析，年龄是男性 SD 的预测因素（P =.014），而焦虑和抑郁（P =.002）和疲劳（P =.043）是女性 SD 的预测因素。在单变量分析中，考虑到过去 15 天（P <.001）和 60 天（P =.001），SD 是 IBD 患者 QoL 的预测因素。在多变量分析中，SD（P =.007）、身体形象扭曲（P <.001）和疲劳（P =.004）是 QoL 低的预测因素（过去 15 天）。与对照组相比，IBD 患者的 SD 更为普遍，且对患者的 QoL 产生负面影响。年龄是男性 SD 的预测因素，而焦虑和抑郁、疲劳是女性 SD 的预测因素。
