Department of Cardiovascular Disease, Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Beijing University of Chinese Medicine, Beijing, China.
Medicine (Baltimore). 2022 Dec 30;101(52):e32599. doi: 10.1097/MD.0000000000032599.
Lipidomics has shaped our knowledge of how lipids play a central role in cardiovascular diseases (CVD), whereas there is a lack of a summary of existing research findings. This study performed a bibliometric analysis of lipidomics research in cardiovascular medicine to reveal the core countries, institutions, key researchers, important references, major journals, research hotspots and frontiers in this field. From 2012 to 2021, a total of 761 articles were obtained from the Web of Science Core Collection database. There is a steady increase of publications yearly. The United States and China are on the top of the list regarding article output. The institutions with the most publications were the Baker Heart and Diabetes Institute, the Chinese Academy of Sciences and Harvard Medical School. Peter J Meikle was both the most published and most co-cited author. The major journal in this field is Journal of lipid research. Keyword co-occurrence analysis indicated that coronary heart disease, mass spectrometry, risk, fatty acid, and insulin resistance have become hot topics in this field and keyword burst detection suggests that metabolomics, activation, liver, low density lipoprotein are the frontiers of research in recent years. Collectively, lipidomics in CVD is still in its infancy with a steady increase yearly. More in-depth studies in this area are warranted in the future.
脂质组学改变了我们对脂质在心血管疾病（CVD）中发挥核心作用的认识，然而，目前缺乏对现有研究结果的总结。本研究对心血管医学中的脂质组学研究进行了文献计量分析，以揭示该领域的核心国家、机构、主要研究人员、重要参考文献、主要期刊、研究热点和前沿。从 2012 年到 2021 年，从 Web of Science 核心合集数据库中获取了 761 篇文章。每年的出版物数量稳步增加。就文章产出而言，美国和中国处于领先地位。发文量最多的机构是贝克心脏和糖尿病研究所、中国科学院和哈佛医学院。Peter J Meikle 既是发文量最多的作者，也是被引频次最多的作者。该领域的主要期刊是《脂质研究杂志》。关键词共现分析表明，冠心病、质谱法、风险、脂肪酸和胰岛素抵抗已成为该领域的热点，关键词突发检测表明，代谢组学、激活、肝脏、低密度脂蛋白是近年来的研究前沿。总之，CVD 中的脂质组学仍处于起步阶段，每年都在稳步增长。未来需要在该领域进行更深入的研究。
