College of Food Science and Technology, Hainan University, Haikou 570228, China; Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Hebei Normal University, Shijiazhuang 050024, China; Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Food Res Int. 2023 Jan;163:112226. doi: 10.1016/j.foodres.2022.112226. Epub 2022 Nov 24.
Increased consumption of high-fat low-fiber foods has been shown to contribute to the development of metabolic syndromes, such as fatty liver, obesity, diabetes, et al. Fermentable dietary fiber, such as inulin, is broadly used to mitigate host metabolic abnormalities. In this work, we studied systematically the effect of inulin on mice with metabolic disorders, induced by either short- or long-term high-fat feeding. As expected, inulin reduced the body weight of mice in both groups. However, it was found that inulin feeding could only increase energy expenditure, alleviate adiposity, and improve glucose intolerance in mice fed with high-fat diet (HFD) for 1 month but not for 4 months. Surprisingly, inulin supplementation could alleviate HFD-induced hepatic steatosis, mediated through increasing adipose triglyceride lipase (ATGL) on liver lipid droplets, in both groups. Gut microbiota in the short- and long-term fat-loaded mice were shown to be modulated differently, which may mediate the differential effects of inulin. These results may help in understanding the role and mechanism of fermentable fiber regulating host metabolism.
研究表明，高脂肪、低纤维食物的摄入增加会导致代谢综合征的发生，如脂肪肝、肥胖症、糖尿病等。可发酵膳食纤维，如菊粉，被广泛用于缓解宿主代谢异常。在这项工作中，我们系统地研究了菊粉对短期或长期高脂肪喂养诱导的代谢紊乱小鼠的影响。正如预期的那样，菊粉降低了两组小鼠的体重。然而，研究发现，菊粉喂养只能增加高脂肪饮食（HFD）喂养 1 个月而不是 4 个月的小鼠的能量消耗，减轻肥胖，改善葡萄糖不耐受。令人惊讶的是，菊粉补充剂可以通过增加肝脏脂肪滴上的脂肪甘油三酯脂肪酶（ATGL）来缓解 HFD 诱导的肝脂肪变性，在这两组中都是如此。短时间和长时间高脂肪喂养的小鼠的肠道微生物群被证明受到不同的调节，这可能介导了菊粉的不同作用。这些结果可能有助于理解可发酵纤维调节宿主代谢的作用和机制。
