辅助放疗与骨肉瘤生存的关系：一项病例对照研究。

The relationship between adjuvant radiotherapy and survival of osteosarcoma: a case-control study.

机构信息

Department of Orthopaedics, 72nd Group Army Hospital, Huzhou University, Huzhou, China.

Department of Orthopedics, Shanghai Changzheng Hospital, Shanghai, China.

出版信息

Biotechnol Genet Eng Rev. 2023 Oct;39(2):796-809. doi: 10.1080/02648725.2022.2163805. Epub 2023 Jan 3.

DOI:10.1080/02648725.2022.2163805

PMID:36596221

Abstract

To investigate whether adjuvant radiotherapy (RT) is associated with survival rate of osteosarcoma patients. A total of 3938 osteosarcoma patients between 1975 and 2016 from Surveillance, Epidemiology, and End Results (SEER) database were enrolled in this study. Survival rate was obtained by Kaplan-Meier method, with log-rank test identifying the difference. Multivariate Cox regression analysis was used to explore independent prognostic factors. The 5-year overall survival (OS) and cancer-specific survival (CSS) rates in surgery plus adjuvant RT group and surgery alone group were 38.2%, 66.3% (OS), and 41.6%, 68% (CSS), respectively. Multivariate analysis showed that adjuvant RT served as the independent unfavorable prognostic factor for OS and CSS. Based on the propensity score matching (PSM) method, the patients who received adjuvant RT had a poorer prognosis. Adjuvant RT showed an association with survival of osteosarcoma. Patients who received adjuvant RT had poorer survival. In the clinical use of adjuvant RT for osteosarcoma, the potential for reduced survival should be considered.

摘要

为了探讨辅助放疗（RT）是否与骨肉瘤患者的生存率相关，本研究共纳入了 1975 年至 2016 年间来自监测、流行病学和最终结果（SEER）数据库的 3938 名骨肉瘤患者。通过 Kaplan-Meier 方法获得生存率，并采用对数秩检验确定差异。多因素 Cox 回归分析用于探索独立的预后因素。手术加辅助 RT 组和单纯手术组的 5 年总生存率（OS）和癌症特异性生存率（CSS）分别为 38.2%、66.3%（OS）和 41.6%、68%（CSS）。多因素分析表明，辅助 RT 是 OS 和 CSS 的独立不良预后因素。基于倾向评分匹配（PSM）方法，接受辅助 RT 的患者预后较差。辅助 RT 与骨肉瘤的生存有关。接受辅助 RT 的患者生存率较低。在骨肉瘤辅助 RT 的临床应用中，应考虑潜在的生存降低。