Division of Cardiovascular Medicine, University of Toledo Medical Center, Toledo, OH, USA.
Division of Medicine, Forrest General Hospital, Hattiesburg, MS, USA.
Vasc Med. 2023 Jun;28(3):205-213. doi: 10.1177/1358863X221140151. Epub 2023 Jan 3.
Peripheral artery disease (PAD) is a common progressive atherosclerotic disease associated with significant morbidity and mortality in the US; however, data regarding PAD-related mortality trends are limited. This study aims to characterize contemporary trends in mortality across sociodemographic and regional groups.
The Centers for Disease Control and Prevention Wide-Ranging OnLine Data for Epidemiologic Research (CDC WONDER) was queried for data regarding PAD-related deaths from 2000 to 2019 in the overall sample and different demographic (age, sex, race/ethnicity) and regional (state, urban-rural) subgroups. Crude and age-adjusted mortality rates (CMR and AAMR, respectively) per 100,000 people were calculated. Associated annual percentage changes (APC) were computed using Joinpoint Regression Program Version 4.9.0.0 trend analysis software.
Between 2000 and 2019, a total of 1,959,050 PAD-related deaths occurred in the study population. Overall, AAMR decreased from 72.8 per 100,000 in 2000 to 32.35 per 100,000 in 2019 with initially decreasing APCs followed by no significant decline from 2016 to 2019. Most demographic and regional subgroups showed initial declines in AAMRs during the study period, with many groups exhibiting no change in mortality in recent years. However, men, non-Hispanic (NH) Black or African American individuals, people aged ⩾ 85 years, and rural counties were associated with the highest AAMRs of their respective subgroups. Notably, there was an increase in crude mortality rate among individuals 25-39 years of age from 2009 to 2019.
Despite initial improvement, PAD-related mortality has remained stagnant in recent years. Disparities have persisted across several demographic and regional groups, requiring further investigation.
外周动脉疾病（PAD）是一种常见的进行性动脉粥样硬化疾病，与美国的高发病率和死亡率密切相关。然而，有关 PAD 相关死亡率趋势的数据有限。本研究旨在描述不同社会人口统计学和地区群体的死亡率的当代趋势。
利用美国疾病控制与预防中心广域在线流行病学研究数据系统（CDC WONDER）查询了 2000 年至 2019 年期间总人群以及不同人口统计学（年龄、性别、种族/族裔）和地区（州、城乡）亚组的 PAD 相关死亡数据。每 10 万人的粗死亡率（CMR）和年龄调整死亡率（AAMR）分别进行计算。使用 Joinpoint Regression Program Version 4.9.0.0 趋势分析软件计算相关的年百分比变化（APC）。
2000 年至 2019 年间，研究人群中共有 1,959,050 例 PAD 相关死亡。总体而言，AAMR 从 2000 年的每 10 万人 72.8 例下降到 2019 年的每 10 万人 32.35 例，最初的 APC 呈下降趋势，随后 2016 年至 2019 年死亡率无明显下降。大多数人口统计学和地区亚组在研究期间均表现出 AAMR 的初始下降，许多组近年来死亡率没有变化。然而，男性、非西班牙裔（NH）黑人或非裔美国人、年龄 ⩾ 85 岁的人群和农村县与各自亚组中最高的 AAMR 相关。值得注意的是，2009 年至 2019 年，25-39 岁人群的粗死亡率有所增加。
尽管最初有所改善，但近年来 PAD 相关死亡率仍保持停滞状态。几个人口统计学和地区群体之间的差异仍然存在，需要进一步调查。
