美国2型糖尿病和肥胖相关死亡率上升：1999年至2022年的一项观察性分析。
Rising mortality rates linked to type-2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022.
作者信息
Ahmed Mushood, Nofal Abdullah, Shafiq Aimen, Javaid Hira, Ahsan Areeba, Nadeem Zain Ali, Ahmed Raheel, Alam Mahboob, Mamas Mamas A, Fudim Marat, Fonarow Gregg C
机构信息
Department of Medicine, Rawalpindi Medical University, Rawalpindi, Pakistan.
Department of Medicine, Services Institute of Medical Sciences, Lahore, Pakistan.
出版信息
J Diabetes Investig. 2025 Mar;16(3):492-500. doi: 10.1111/jdi.14386. Epub 2024 Dec 19.
BACKGROUND
The prevalence of type 2 diabetes (T2D) and obesity are increasing in the United States. However, population-level data for mortality trends due to T2D and obesity are limited. This study aims to assess these death trends among adults in the United States categorized by sex, race, and geographical location.
METHODS
We queried the CDC-WONDER database for multiple cause of death data of adults aged ≥25 years. The crude mortality rates (CMR), age-adjusted mortality rates (AAMRs), annual percent change (APC), and the average APC (AAPC) along with a 95% confidence interval (CI) were analyzed.
RESULTS
From 1999 to 2022, a total of 88,597 T2DM and obesity-related deaths were recorded in the United States. The AAMR consistently increased from 1999 to 2017 (APC: 7.64; 95% CI: 1.91-9.96), followed by a marked rise from 2017 to 2022 (APC: 20.13; 95% CI: 12.88-38.57). The AAMR was approximately 3.58 times higher during the COVID-19 pandemic compared to the period from 1999 to 2019. The AAMR for males was consistently greater than that for females. The highest AAMR was observed in non-Hispanic (NH) Blacks or African Americans, followed by NH White, Hispanic or Latino, and other NH populations. Rural areas (AAMR: 1.86, 95% CI: 1.83-1.89) exhibited a greater AAMR than urban regions 1.26 (95% CI: 1.25-1.27).
CONCLUSIONS
Our results indicate a substantial increasing trend of T2D and obesity-related deaths in the United States especially during the COVID-19 pandemic.
背景
2型糖尿病（T2D）和肥胖症在美国的患病率正在上升。然而，关于T2D和肥胖症所致死亡率趋势的人群水平数据有限。本研究旨在评估按性别、种族和地理位置分类的美国成年人中的这些死亡趋势。
方法
我们查询了美国疾病控制与预防中心（CDC）的WONDER数据库，获取25岁及以上成年人的多种死因数据。分析了粗死亡率（CMR）、年龄调整死亡率（AAMR）、年度百分比变化（APC）以及平均APC（AAPC）及其95%置信区间（CI）。
结果
1999年至2022年期间，美国共记录了88597例与T2DM和肥胖相关的死亡病例。AAMR从1999年到2017年持续上升（APC：7.64；95%CI：1.91 - 9.96），随后在2017年至2022年期间显著上升（APC：20.13；95%CI：12.88 - 38.57）。与1999年至2019年期间相比，COVID - 19大流行期间的AAMR高出约3.58倍。男性的AAMR一直高于女性。非西班牙裔（NH）黑人或非裔美国人的AAMR最高，其次是NH白人、西班牙裔或拉丁裔以及其他NH人群。农村地区（AAMR：1.86，95%CI：1.83 - 1.89）的AAMR高于城市地区（1.26，95%CI：1.25 - 1.27）。
结论
我们的结果表明，在美国，尤其是在COVID - 19大流行期间，与T2D和肥胖相关的死亡病例呈大幅上升趋势。
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