Onoue Ryotaro, Watanabe Hiroyuki, Ono Masahiro
Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.
Chem Commun (Camb). 2023 Jan 19;59(7):928-931. doi: 10.1039/d2cc05405a.
Targeted radionuclide therapy using Auger electrons is a promising strategy in cancer treatment. A DNA-binding Hoechst-tagged radioiodinated BODIPY derivative ([I]BH) has been prepared as an Auger therapeutic agent. [I]BH showed high accumulation in the nucleus of HeLa cells and cytotoxicity caused by DNA double-strand breaks.
利用俄歇电子进行靶向放射性核素治疗是癌症治疗中一种很有前景的策略。一种与DNA结合的、带有Hoechst标记的放射性碘化硼二吡咯衍生物（[I]BH）已被制备为一种俄歇治疗剂。[I]BH在HeLa细胞核中显示出高积累，并具有由DNA双链断裂引起的细胞毒性。
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