调节过程中中央和周边脉络膜厚度及眼轴长度的变化。

Central and peripheral choroidal thickness and eye length changes during accommodation.

作者信息

Kaphle Dinesh, Schmid Katrina L, Suheimat Marwan, Read Scott A, Atchison David A

机构信息

Centre for Vision and Eye Research, Queensland University of Technology, Brisbane, Queensland, Australia.

Discipline of Optometry, Faculty of Health, University of Canberra, Bruce, Australian Capital Territory, Australia.

出版信息

Ophthalmic Physiol Opt. 2023 May;43(3):311-318. doi: 10.1111/opo.13084. Epub 2023 Jan 4.

DOI:10.1111/opo.13084

PMID:36597948

Abstract

PURPOSE

Eye length increases during accommodation, both on-axis and in the periphery. The aim of this study was to determine whether the peripheral choroid thins with accommodation and to determine the relationship with eye length changes measured at the same location.

METHODS

Subjects included 53 young adults in good ocular and general health, with 19 emmetropes and 34 myopes. Measurements from the right eye were made for 0 D and 6 D accommodation stimuli for ±30° horizontal visual field/retinal locations in 10° steps. Valid eye length and choroidal thickness measurements were obtained for 37 and 47 participants, respectively, and both measures were taken for 31 participants. 2.5% phenylephrine was instilled to dilate the pupils. Participants turned their eyes, without head movement, to fixate targets and to make the target 'as clear as possible' during measurements. Correction was made for the influence of lens thickness changing at different peripheral angles. Choroidal thickness was measured with a spectral-domain-Optical Coherence Tomographer. For peripheral images, the internal cross target on the capture screen was moved from the centre to 17.25° nasal/temporal positions.

RESULTS

In accordance with previous literature, eye length increased with accommodation. The greatest change (mean ± SD) of 41 ± 17 μm occurred at the centre, with a mean change across the locations of 33 μm. There were no significant differences between emmetropes and myopes. Choroidal thickness decreased with accommodation, with changes being about two-thirds of those occurring for eye length. The greatest change of -30 ± 1 μm occurred at the centre, with a mean change of -21 μm. Greater choroidal thinning occurred for myopes than for emmetropes (23 ± 11 vs. 17 ± 8 μm, p = 0.02).

CONCLUSIONS

With accommodation, eye length increased and the choroid thinned, at both central and peripheral positions. Choroidal thinning accounted for approximately 60% of the eye length increase across the horizontal ±30°.

摘要

目的

在调节过程中，眼轴长度在视轴上和周边都会增加。本研究的目的是确定周边脉络膜是否会随着调节而变薄，并确定其与在同一位置测量的眼轴长度变化之间的关系。

方法

研究对象包括53名眼部和全身健康状况良好的年轻人，其中19名正视眼者和34名近视眼者。对右眼在0D和6D调节刺激下，以10°步长对水平视野/视网膜位置±30°进行测量。分别有37名和47名参与者获得了有效的眼轴长度和脉络膜厚度测量值，31名参与者同时进行了这两项测量。滴入2.5%的去氧肾上腺素以散瞳。参与者在测量过程中转动眼睛，头部不动，注视目标并使目标“尽可能清晰”。对不同周边角度下晶状体厚度变化的影响进行了校正。使用光谱域光学相干断层扫描仪测量脉络膜厚度。对于周边图像，将采集屏幕上的内部交叉目标从中心移动到鼻侧/颞侧17.25°位置。

结果

与先前文献一致，眼轴长度随调节而增加。最大变化（平均值±标准差）为41±17μm，发生在中心位置，各位置的平均变化为33μm。正视眼者和近视眼者之间无显著差异。脉络膜厚度随调节而降低，变化约为眼轴长度变化的三分之二。最大变化为-30±1μm，发生在中心位置，平均变化为-21μm。近视眼的脉络膜变薄程度大于正视眼者（23±11 vs. 17±8μm，p = 0.02）。