Cotoi S, Caraşca E, Incze A, Pop H, Podoleanu D, Moldovan D
Institute of Medicine, Third Medical Clinic, Tirgu Mures, Romania.
Med Interne. 1987 Jul-Sep;25(3):191-3.
In order to eliminate the first pass through the liver where the drug is deactivated, 80 mgs verapamil was given in sublingual way in a) 10 patients with supraventricular tachycardias where in 7 instances sinus rhythm was obtained after 15-30 minutes, b) in 18 patients with atrial fibrillation and in 5 with atrial flutter with rapid ventricular rate, where a significant slowing down of ventricular rate was obtained after 20 minutes. The sublingual way of verapamil administration is a simple, effective and safe procedure in the treatment of tachyarrhythmias.
为消除药物在肝脏首过效应（药物在肝脏失活），对以下患者采用舌下含服80毫克维拉帕米的方式进行治疗：a) 10例室上性心动过速患者，其中7例在15 - 30分钟后恢复窦性心律；b) 18例心房颤动患者和5例伴有快速心室率的心房扑动患者，这些患者在20分钟后心室率显著减慢。舌下含服维拉帕米是治疗快速性心律失常的一种简单、有效且安全的方法。
