Cuianu M, Nussbaum A, Cristea A, Vlăduţiu T, Roman S, Stoica D
Medical Clinic No. I, Department of Endocrinology, Cluj-Napoca, Romania.
Med Interne. 1987 Jul-Sep;25(3):205-10.
Both von Willebrand factor antigen and activity tested as ristocetin cofactor, were found to be increased in the 20 patients with hyperthyroidism, while changes detected on the 10 hypothyroid patients did not significantly differ from the mean values recorded in 19 healthy control subjects. It is considered that the high levels of endothelia-derived plasma von Willebrand factor in hyperthyroidism is the result of a long-standing stimulation of vascular endothelial cells by either a direct effect of thyroid hormones or by an excessive adrenergic activity. The present findings represent an important limitation in interpreting raised levels of plasma von Willebrand factor as a marker of endothelial injury or in terms of a thrombotic tendency.
在20例甲状腺功能亢进患者中，血管性血友病因子抗原以及作为瑞斯托菌素辅因子检测的活性均升高，而10例甲状腺功能减退患者检测到的变化与19例健康对照受试者记录的平均值无显著差异。据认为，甲状腺功能亢进症中内皮源性血浆血管性血友病因子水平升高是甲状腺激素的直接作用或过度的肾上腺素能活性长期刺激血管内皮细胞的结果。目前的研究结果对将血浆血管性血友病因子水平升高解释为内皮损伤标志物或血栓形成倾向方面存在重要限制。
