Deng L, Bremme K, Hansson L O, Blombäck M
Division of Obstetrics and Gynecology, Karolinska Hospital/Karolinska Institute, Stockholm, Sweden.
Obstet Gynecol. 1994 Dec;84(6):941-5.
To evaluate the levels of von Willebrand factor and fibronectin as markers for the severity of endothelial cell injury in preeclampsia.
In 63 pregnant women with preeclampsia, the plasma levels of von Willebrand factor and fibronectin were measured as soon as symptoms were detected, at 5 weeks postpartum, and after lactation. They were also compared with levels in 29 normotensive pregnant women. The von Willebrand factor was measured by enzyme-linked immunoassay and fibronectin was measured using an automated immunonephelometric method.
In preeclampsia, the levels of von Willebrand factor and fibronectin were higher than in normal pregnancy samples drawn in the second and third trimesters. The levels of fibronectin were still elevated at 5 weeks postpartum in women with severe preeclampsia. Four patients with severe preeclampsia who were studied frequently had high levels of von Willebrand factor 5 weeks postpartum.
The increased maternal plasma levels of von Willebrand factor and fibronectin indicate that endothelial stimulation is present during preeclampsia. The high fibronectin values found even 5 weeks after delivery, at least in patients with severe preeclampsia, may indicate an ongoing vascular disease with increased risk for preeclampsia in subsequent pregnancies.
评估血管性血友病因子（von Willebrand factor）和纤连蛋白水平作为子痫前期内皮细胞损伤严重程度标志物的情况。
对63例子痫前期孕妇，在症状出现时、产后5周及哺乳期结束时测定其血浆血管性血友病因子和纤连蛋白水平。并将这些水平与29例血压正常的孕妇进行比较。血管性血友病因子采用酶联免疫吸附测定法检测，纤连蛋白采用自动免疫比浊法检测。
子痫前期患者血管性血友病因子和纤连蛋白水平高于孕中期和孕晚期正常妊娠样本。重度子痫前期患者产后5周纤连蛋白水平仍升高。对4例重度子痫前期患者进行频繁研究发现，其产后5周血管性血友病因子水平较高。
孕妇血浆中血管性血友病因子和纤连蛋白水平升高表明子痫前期存在内皮细胞激活。即使在分娩后5周，至少在重度子痫前期患者中发现的高纤连蛋白值，可能表明存在持续性血管疾病，增加了后续妊娠发生子痫前期的风险。
