孤立性快速眼动睡眠行为障碍中的胆碱能核 4 退化和认知障碍。
Cholinergic Nucleus 4 Degeneration and Cognitive Impairment in Isolated Rapid Eye Movement Sleep Behavior Disorder.
机构信息
Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Department of Neurology, Virginia Commonwealth University, Richmond, Virginia, USA.
出版信息
Mov Disord. 2023 Mar;38(3):474-479. doi: 10.1002/mds.29306. Epub 2023 Jan 4.
BACKGROUND
Cholinergic nucleus 4 (Ch4) degeneration is associated with cognitive impairment in Parkinson's disease and dementia with Lewy bodies, but it is unknown if Ch4 degeneration is also present in isolated rapid eye movement sleep behavior disorder (iRBD).
OBJECTIVE
The aim was to determine if there is evidence of Ch4 degeneration in patients with iRBD and if it is associated with cognitive impairment.
METHODS
We analyzed the clinical and neuropsychological data of 35 iRBD patients and 35 age- and sex-matched healthy controls. Regional gray matter density (GMD) was calculated for Ch4 using probabilistic maps applied to brain magnetic resonance imaging (MRI).
RESULTS
Ch4 GMD was significantly lower in the iRBD group compared to controls (0.417 vs. 0.441, P = 0.02). Ch4 GMD was also found to be a significant predictor of letter number sequencing (β-coefficient = 58.31, P = 0.026, 95% confidence interval [7.47, 109.15]), a measure of working memory.
CONCLUSIONS
iRBD is associated with Ch4 degeneration, and Ch4 degeneration in iRBD is associated with impairment in working memory. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
背景
胆碱能核 4（Ch4）退化与帕金森病和路易体痴呆的认知障碍有关，但 Ch4 退化是否也存在于孤立性快速眼动睡眠行为障碍（iRBD）中尚不清楚。
目的
本研究旨在确定 iRBD 患者是否存在 Ch4 退化的证据，以及 Ch4 退化是否与认知障碍有关。
方法
我们分析了 35 例 iRBD 患者和 35 名年龄和性别匹配的健康对照者的临床和神经心理学数据。使用概率图谱对脑磁共振成像（MRI）进行分析，计算 Ch4 的区域灰质密度（GMD）。
结果
与对照组相比，iRBD 组的 Ch4 GMD 显著降低（0.417 比 0.441，P = 0.02）。Ch4 GMD 也是字母数字排序（β系数= 58.31，P = 0.026，95%置信区间[7.47，109.15]），一种工作记忆的衡量标准的显著预测指标。
结论
iRBD 与 Ch4 退化有关，iRBD 中的 Ch4 退化与工作记忆障碍有关。© 2023 作者。运动障碍由 Wiley Periodicals LLC 代表国际帕金森病和运动障碍协会出版。
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