Palliative Care Department, Institut Català d'Oncologia, Badalona, Spain
School of Medicine and Health Sciences, Universitat Internacional de Catalunya, Barcelona, Spain.
BMJ Support Palliat Care. 2024 Jan 8;13(e3):e585-e596. doi: 10.1136/spcare-2022-003653.
Breatlessness flares directly impair quality of life of patients with cancer. The aim of this review was to analyse and synthesise the available information related to its terminology, definition and clinical features in patients with cancer.
Integrative systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Literature search was conducted in MEDLINE PubMed, CINAHLPlus, Web of Science, Cochrane Central Register Controlled Trials CENTRAL, Scopus and OpenAire.
Data from 1065 patients with cancer included in 12 studies were analysed. The preferred term for breathlessness flares was episodic dyspnoea (ED). The reported frequency of ED was 20.4% (70.9% in patients reporting background dyspnoea (BD)). ED intensity was moderate to severe with short duration (<10 min) in >80% of patients. The most common trigger was exertion (>90%) followed by emotional or environmental factors. ED management consisted mainly of pharmacological and non-pharmacological measures.
This systematic review shows that ED is common in patients with cancer, especially in those with BD. Further studies are urgently needed to better understand this condition and to develop specific therapeutic management.
CRD42019126708.
呼吸困难急性发作直接影响癌症患者的生活质量。本综述旨在分析和综合有关癌症患者呼吸困难急性发作的术语、定义和临床特征的现有信息。
根据系统评价和荟萃分析报告的首选项目进行综合系统评价。在 MEDLINE PubMed、CINAHLPlus、Web of Science、Cochrane 中央对照试验注册中心 CENTRAL、Scopus 和 OpenAire 进行文献检索。
对纳入的 12 项研究中的 1065 例癌症患者的数据进行了分析。呼吸困难急性发作的首选术语为发作性呼吸困难（ED）。报告的 ED 频率为 20.4%（报告背景性呼吸困难（BD）的患者中为 70.9%）。ED 强度为中重度，持续时间短（<10 分钟），>80%的患者有此情况。最常见的诱因是体力活动（>90%），其次是情绪或环境因素。ED 的管理主要包括药物和非药物措施。
本系统综述表明，ED 在癌症患者中很常见，尤其是在那些有 BD 的患者中。迫切需要进一步研究以更好地了解这种情况，并制定特定的治疗管理方法。
PROSPERO 注册号：CRD42019126708。
