Chang Rong-Kun, Badawy Sherif, Hussain Munir A, Buehler John D
The DuPont Merck Pharmaceutical Company, Wilmington, Delaware, 19880.
Duquesne University, Pittsburgh, PA, 15282.
Drug Dev Ind Pharm. 1995;21(3):361-368. doi: 10.3109/03639049509048116.
The performance of a modified V-shaped solids mixer, i.e., uneven leg or offset angle, has been reassessed by using a binary cohesive mixture, made up of 1% sodium salicylate and 99% microcry stalline cellulose, as the mixing system. The performance of the mixer was defined in terms of relative standard deviation from the measured mean. The results generated from the present study were compared with the previously published data generated by using a free-flow mixing system. It appears in the present study that the free-flowing, segregating materials may be used as a mixing model to predict the trend of the performance of a modified V-shaped blender for the non-free-flowing, cohesive materials. However, in the equilibrium state, the non-free-flowing, cohesive mixture has much better quality of the mix than that of the free-flowing, segregating system in terms of the scale and intensity of segregation.
已使用由1%水杨酸钠和99%微晶纤维素组成的二元粘性混合物作为混合体系，重新评估了改良V形固体混合器（即腿不均匀或有偏置角）的性能。混合器的性能是根据测量平均值的相对标准偏差来定义的。将本研究产生的结果与先前发表的使用自由流动混合体系产生的数据进行了比较。在本研究中似乎可以用自由流动、会产生离析的物料作为混合模型，来预测改良V形搅拌器对于非自由流动、有粘性的物料的性能趋势。然而，在平衡状态下，就离析的规模和强度而言，非自由流动、有粘性的混合物的混合质量比自由流动、会产生离析的体系要好得多。
