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姜黄相关药物性肝损伤

Turmeric-Associated Drug-Induced Liver Injury.

作者信息

Sunagawa Shawnalyn W, Houlihan Conor, Reynolds Brandon, Kjerengtroen Sara, Murry Daryl J, Khoury Nathalie

机构信息

Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, NE.

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE.

出版信息

ACG Case Rep J. 2022 Dec 26;9(12):e00941. doi: 10.14309/crj.0000000000000941. eCollection 2022 Dec.

DOI:10.14309/crj.0000000000000941
PMID:36600786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9794274/
Abstract

Turmeric is a common herbal supplement used for its possible anti-inflammatory and other properties. It is marketed as safe with few reports of major adverse effects directly related to oral supplementation. We report a case of turmeric supplement-induced liver injury in a 49-year-old woman admitted with elevated aspartate aminotransferase and alanine aminotransferase with no history of liver disease or alcohol use disorder. Thus, this case re-emphasizes the importance of evaluating herbal and dietary supplements as potential drug-induced liver injury causes.

摘要

姜黄是一种常见的草药补充剂,因其可能具有的抗炎及其他特性而被使用。它在市场上被宣传为安全产品,很少有与口服补充剂直接相关的重大不良反应报告。我们报告了一例49岁女性因服用姜黄补充剂导致肝损伤的病例,该患者因天冬氨酸转氨酶和丙氨酸转氨酶升高入院,既往无肝病或酒精使用障碍病史。因此,该病例再次强调了评估草药和膳食补充剂作为药物性肝损伤潜在病因的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62b1/9794274/38210a075c77/ac9-9-e00941-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62b1/9794274/e958f5275492/ac9-9-e00941-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62b1/9794274/38210a075c77/ac9-9-e00941-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62b1/9794274/e958f5275492/ac9-9-e00941-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62b1/9794274/38210a075c77/ac9-9-e00941-g002.jpg

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本文引用的文献

1
Liver Injury Associated with Turmeric-A Growing Problem: Ten Cases from the Drug-Induced Liver Injury Network [DILIN].与姜黄相关的肝损伤:药物性肝损伤网络(DILIN)的 10 个病例报告。
Am J Med. 2023 Feb;136(2):200-206. doi: 10.1016/j.amjmed.2022.09.026. Epub 2022 Oct 14.
2
Improving Curcumin Bioavailability: Current Strategies and Future Perspectives.提高姜黄素的生物利用度:当前策略与未来展望
Pharmaceutics. 2021 Oct 17;13(10):1715. doi: 10.3390/pharmaceutics13101715.
3
Autoimmune Hepatitis Associated With Turmeric Consumption.
与食用姜黄相关的自身免疫性肝炎。
ACG Case Rep J. 2020 Mar 16;7(3):e00320. doi: 10.14309/crj.0000000000000320. eCollection 2020 Mar.
4
Meta-analysis of randomized controlled trials of 4 weeks or longer suggest that curcumin may afford some protection against oxidative stress.荟萃分析 4 周或更长时间的随机对照试验表明,姜黄素可能对氧化应激提供一些保护。
Nutr Res. 2018 Dec;60:1-12. doi: 10.1016/j.nutres.2018.08.003. Epub 2018 Sep 4.
5
Drug-induced autoimmune hepatitis associated with turmeric dietary supplement use.与姜黄膳食补充剂使用相关的药物性自身免疫性肝炎。
BMJ Case Rep. 2018 Sep 10;2018:bcr-2018-224611. doi: 10.1136/bcr-2018-224611.
6
Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects.分析不同姜黄素创新配方,以提高人体的相对口服生物利用度。
Eur J Nutr. 2018 Apr;57(3):929-938. doi: 10.1007/s00394-016-1376-9. Epub 2017 Feb 16.
7
RUCAM in Drug and Herb Induced Liver Injury: The Update.药物及草药所致肝损伤的RUCAM:最新进展
Int J Mol Sci. 2015 Dec 24;17(1):14. doi: 10.3390/ijms17010014.
8
Therapeutic potential of curcumin and curcumin analogues in rheumatology.姜黄素及姜黄素类似物在风湿病学中的治疗潜力。
Int J Rheum Dis. 2015 Jul;18(6):591-3. doi: 10.1111/1756-185X.12753.
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Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network.美国药物性肝损伤网络中来自草药和膳食补充剂的肝损伤
Hepatology. 2014 Oct;60(4):1399-408. doi: 10.1002/hep.27317. Epub 2014 Aug 25.
10
Comparative absorption of curcumin formulations.姜黄素制剂的比较吸收情况。
Nutr J. 2014 Jan 24;13:11. doi: 10.1186/1475-2891-13-11.