Shrestha Atul, Elliott Sarah, Abasszade Joshua Haron, Wu Kyle, Worland Thomas, Simpson Ian, Dev Anouk
Department of Gastroenterology and Hepatology, Monash Health, Clayton, VIC, Australia.
Department of Anatomical Pathology, Monash Health, Clayton, VIC, Australia.
Case Rep Gastroenterol. 2025 Feb 24;19(1):96-106. doi: 10.1159/000543679. eCollection 2025 Jan-Dec.
Turmeric is a common spice used in traditional Chinese and Ayurvedic medicine for a variety of purported health benefits. Recent concerns have arisen regarding turmeric-induced liver injury linked to formulations with enhanced bioavailability, often including piperine found in black pepper.
We explore a case of a 40-year-old female with increasing fatigue, pruritus, and dark urine following consumption of turmeric and black pepper "wellness shots" leading to a significant drug-induced liver injury.
This case underscores the critical need to recognise herbal remedies, such as turmeric, as potential sources of hepatotoxicity. Despite a reputation of safety, limited regulation and testing of turmeric may mean potential adverse effects are under-recognised. Understanding the mechanisms behind turmeric and black pepper's hepatotoxicity, including the role of potential genetic predispositions, requires further investigation for its safe use.
姜黄是一种常见的香料，在中国传统医学和阿育吠陀医学中使用，据称有多种健康益处。最近，人们对姜黄引起的肝损伤产生了担忧，这种损伤与生物利用度增强的配方有关，这些配方通常含有黑胡椒中的胡椒碱。
我们探讨了一例40岁女性的病例，该女性在饮用姜黄和黑胡椒“健康饮品”后出现疲劳、瘙痒和深色尿液加重的情况，导致严重的药物性肝损伤。
该病例强调了认识到姜黄等草药疗法可能是肝毒性潜在来源的迫切需求。尽管姜黄有安全的声誉，但对其监管和测试有限可能意味着潜在的不良反应未得到充分认识。了解姜黄和黑胡椒肝毒性背后的机制，包括潜在遗传易感性的作用，需要进一步研究以确保其安全使用。
