Hussein Hossam A, Alqannass Ali M, Al Mansour Mohammed H, Safhi Ahmed A
Otorhinolaryngology, King Khalid Hospital, Najran, SAU.
Otorhinolaryngology, Menoufiya University, Shebien Elkoom, EGY.
Cureus. 2022 Nov 30;14(11):e32083. doi: 10.7759/cureus.32083. eCollection 2022 Nov.
Background Studies have reported that the rate of upper respiratory tract infections in children and adults is inversely related to serum vitamin D levels and supplementation with vitamin D reduces the incidence of this infection. This study aimed to examine if vitamin D serum levels were a risk factor for recurrent tonsillitis among adult patients. Methods Retrospective comparative analysis was carried out on 100 patients diagnosed with recurrent tonsillitis with 100 age- and sex-matched individuals as controls between June 2016 and May 2022. Tonsillar size was assessed based on Brodsky grading system. Serum levels of 25-hydroxy (25(OH)) vitamin D, total calcium, iron, hemoglobin, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were analyzed. Results There was a statistically significant low vitamin D levels in tonsil size grades III+IV compared to grade I+II (p <0.001) among cases. There was a significantly lower serum value for 25(OH) vitamin D in the cases as compared to the control group (p <0.001). A high percentage (68%) of cases had vitamin D deficiency (<20 ng/mL) and this was statistically significant (p <0.001). There were statistically significant higher values of CRP and ESR among cases compared to the control group (p <0.001). At a cut off (≤21.2), serum vitamin D levels achieved 78% sensitivity, 65% specificity (p <0.001) to differentiate cases from controls. Following logistic regression analysis, the level of vitamin D was the only significant risk factor. Conclusion Findings from our study also suggest an association between recurrent tonsillitis among our adult cohorts and low serum 25(OH) vitamin D levels. Therefore, we opine that serum vitamin D levels should be considered in the management of adult patients with tonsillitis.
研究报告称，儿童和成人上呼吸道感染的发生率与血清维生素D水平呈负相关，补充维生素D可降低这种感染的发生率。本研究旨在探讨血清维生素D水平是否为成年患者复发性扁桃体炎的危险因素。方法：对2016年6月至2022年5月期间诊断为复发性扁桃体炎的100例患者和100例年龄和性别匹配的个体作为对照进行回顾性比较分析。根据布罗德斯基分级系统评估扁桃体大小。分析血清25-羟基（25(OH)）维生素D、总钙、铁、血红蛋白、C反应蛋白（CRP）和红细胞沉降率（ESR）水平。结果：病例组中，扁桃体大小III+IV级的维生素D水平显著低于I+II级（p<0.001）。与对照组相比，病例组的25(OH)维生素D血清值显著降低（p<0.001）。高比例（68%）的病例存在维生素D缺乏（<20 ng/mL），且具有统计学意义（p<0.001）。与对照组相比，病例组的CRP和ESR值在统计学上显著更高（p<0.001）。在截断值（≤21.2）时，血清维生素D水平区分病例与对照的敏感度为78%，特异度为65%（p<0.001）。经过逻辑回归分析，维生素D水平是唯一的显著危险因素。结论：我们的研究结果还表明，成年队列中的复发性扁桃体炎与低血清25(OH)维生素D水平之间存在关联。因此，我们认为在成年扁桃体炎患者的管理中应考虑血清维生素D水平。
