Zhang Lei, Liu Huan-Huan, Li Feng, Yang Fan, Qian Ling-Ling, Wang Ru-Xing
Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, People's Republic of China.
Wuxi School of Medicine, Jiangnan University, Wuxi, People's Republic of China.
J Inflamm Res. 2022 Dec 29;15:6883-6889. doi: 10.2147/JIR.S390310. eCollection 2022.
Diabetes is a significant risk factor for arrhythmias. However, the pathophysiology of diabetes-related arrhythmias still needs to be elucidated, presumably associated with structural and electrical remodeling. There is growing evidence that inflammation and arrhythmias are intimately associated, which has spurred significant interest in exploring the regulatory links in diabetes. Recent research findings have revealed a vital role for the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome signaling, and facilitated the occurrence of arrhythmias in diabetes, including NLRP3 inflammasome activation by multiple stressors and its downstream cytokines, interleukin-1β (IL-1β) and interleukin-18 (IL-18). This narrative review aims to summarize the complex interaction between NLRP3 inflammasomes signaling and diabetes-related arrhythmias. Articles regarding the role of NLRP3 inflammasome in diabetes-related arrhythmias and relevant mechanisms were selected. Relevant articles were selected from PubMed. The search terms were "NLRP3 inflammasome" and "diabetes" and "arrhythmia". Important references from selected articles were also retrieved. The role of NLRP3 inflammasome signaling in diabetes-induced arrhythmias may provide a new option for the prevention and treatment diabetes-related arrhythmias.
糖尿病是心律失常的一个重要危险因素。然而，糖尿病相关心律失常的病理生理学仍有待阐明，可能与结构和电重构有关。越来越多的证据表明炎症与心律失常密切相关，这激发了人们对探索糖尿病中调节联系的浓厚兴趣。最近的研究发现揭示了含NOD样受体家族吡咯结构域蛋白3（NLRP3）炎性小体信号传导的重要作用，并促进了糖尿病中心律失常的发生，包括多种应激源激活NLRP3炎性小体及其下游细胞因子白细胞介素-1β（IL-1β）和白细胞介素-18（IL-18）。这篇叙述性综述旨在总结NLRP3炎性小体信号传导与糖尿病相关心律失常之间的复杂相互作用。我们选择了关于NLRP3炎性小体在糖尿病相关心律失常中的作用及相关机制的文章。相关文章从PubMed中选取。检索词为“NLRP3炎性小体”、“糖尿病”和“心律失常”。还检索了所选文章的重要参考文献。NLRP3炎性小体信号传导在糖尿病诱导的心律失常中的作用可能为糖尿病相关心律失常的预防和治疗提供新的选择。
