吡罗昔康与曲马多在口腔外科手术中的超前镇痛效果比较
Pre-emptive analgesia efficacy of piroxicam versus tramadol in oral surgery.
作者信息
Muthuluri Tejdeep, Chandrupatla Siddardha Gowtam, Rajan Ritesh, Reddy Viveka V, Jhawar Dinesh K, Potturi Abhinand
机构信息
Department of Oral & Maxillofacial Surgery, SVS Institute of Medical & Dental Sciences, Mehaboobnagar, TG, India.
Public Health Dentist, Ibn Sina Foundation, Houston, Texas, USA.
出版信息
J Dent Anesth Pain Med. 2022 Dec;22(6):443-450. doi: 10.17245/jdapm.2022.22.6.443. Epub 2022 Nov 24.
BACKGROUND
This double-blind randomized controlled trial (RCT) was conducted to evaluate the pre-emptive analgesia and anti-inflammatory efficacy of piroxicam compared with tramadol in patients undergoing oral surgery.
METHODS
Seventy-eight patients who required extraction of impacted mandibular third molars were randomized into three treatment groups of 26 patients each: group I received 100 mg of tramadol, group II received 20 mg of piroxicam, and group III received a placebo. Drugs were administered intramuscularly 30 min prior to the extraction procedure.
RESULTS
Pain intensity, time to first analgesic administration, total analgesic consumption, facial edema, and trismus were the outcomes of interest. The group receiving 20 mg of piroxicam showed significantly lower pain intensity, increased time to first analgesic, and reduced edema from preoperative to postoperative day seven than those in the tramadol and placebo groups.
CONCLUSION
The findings of this study showed that piroxicam had significant pain relief efficacy after third molar surgery compared with that in tramadol.
背景
本双盲随机对照试验（RCT）旨在评估吡罗昔康与曲马多相比，在接受口腔手术患者中的超前镇痛和抗炎疗效。
方法
78例需要拔除下颌阻生第三磨牙的患者被随机分为三个治疗组，每组26例：第一组接受100mg曲马多，第二组接受20mg吡罗昔康，第三组接受安慰剂。在拔牙手术前30分钟肌肉注射给药。
结果
疼痛强度、首次使用镇痛药的时间、镇痛药总消耗量、面部水肿和牙关紧闭是感兴趣的结果。与曲马多组和安慰剂组相比，接受20mg吡罗昔康的组在术后第7天的疼痛强度显著降低，首次使用镇痛药的时间延长，水肿减轻。
结论
本研究结果表明，与曲马多相比，吡罗昔康在第三磨牙手术后具有显著的镇痛效果。
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