Antunes Flavia Tasmin Techera, De Souza Alessandra Hubner, Figueira Juliana, Binda Nancy Scardua, Carvalho Vanice Paula Ricardo, Vieira Luciene Bruno, Gomez Marcus Vinícius
Department of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.
2 Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
Front Cell Dev Biol. 2022 Dec 19;10:1090765. doi: 10.3389/fcell.2022.1090765. eCollection 2022.
Calcium (Ca ) is an important second messenger in charge of many critical processes in the central nervous system (CNS), including membrane excitability, neurotransmission, learning, memory, cell proliferation, and apoptosis. In this way, the voltage-gated calcium channels (VGCCs) act as a key supply for Ca entry into the cytoplasm and organelles. Importantly, the dysregulation of these channels has been reported in many neurological diseases of young-onset, with associated genetic factors, such as migraine, multiple sclerosis, and Huntington's disease. Notably, the literature has pointed to the role of N-type Ca channels (NTCCs) in controlling a variety of processes, including pain, inflammation, and excitotoxicity. Moreover, several Ca channel blockers that are used for therapeutic purposes have been shown to act on the N-type channels. Therefore, this review provides an overview of the NTCCs in neurological disorders focusing mainly on Huntington's disease, multiple sclerosis, and migraine. It will discuss possible strategies to generate novel therapeutic strategies.
钙（Ca ）是一种重要的第二信使，负责中枢神经系统（CNS）中的许多关键过程，包括膜兴奋性、神经传递、学习、记忆、细胞增殖和细胞凋亡。通过这种方式，电压门控钙通道（VGCCs）作为Ca进入细胞质和细胞器的关键供应途径。重要的是，在许多早发性神经疾病中已报道这些通道的失调与相关遗传因素有关，如偏头痛、多发性硬化症和亨廷顿舞蹈症。值得注意的是，文献指出N型钙通道（NTCCs）在控制多种过程中发挥作用，包括疼痛、炎症和兴奋性毒性。此外，几种用于治疗目的的钙通道阻滞剂已被证明作用于N型通道。因此，本综述概述了神经疾病中的NTCCs，主要聚焦于亨廷顿舞蹈症、多发性硬化症和偏头痛。它将讨论生成新型治疗策略 的可能策略。
