钙、镁、锌和铜摄入量与糖尿病患者糖尿病视网膜病变的关系：2007-2018 年全国健康与营养调查。
Association of Calcium, Magnesium, Zinc, and Copper Intakes with Diabetic Retinopathy in Diabetics: National Health and Nutrition Examination Survey, 2007-2018.
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China.
出版信息
Curr Eye Res. 2023 May;48(5):485-491. doi: 10.1080/02713683.2023.2165105. Epub 2023 Jan 4.
PURPOSE
To evaluate the associations between calcium, magnesium, zinc, and copper intakes and the risk of diabetic retinopathy (DR) in US diabetes adults.
METHODS
Using data from the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Multivariable logistic regression models and restricted cubic spline models were applied to examine the associations between total calcium, magnesium, zinc, and copper intakes and diabetic retinopathy.
RESULTS
A total of 3794 adults aged 40 years or older were included. Higher quartile intake of calcium, magnesium, zinc, and copper was associated with a lower occurrence of DR, the multivariate adjusted ORs (95% CI) were 0.57 (0.38-0.86), 0.48 (0.32-0.73), 0.58 (0.39-0.88), and 0.48 (0.30-0.77), respectively. U-shaped dose-response relationships were found between calcium, magnesium, zinc, copper intake, and the risk of DR.
CONCLUSION
Higher total calcium, magnesium, zinc, and copper intake were inversely associated with the risk of DR in US diabetes adults.
目的
评估钙、镁、锌和铜的摄入量与美国糖尿病成年人糖尿病视网膜病变（DR）风险之间的关联。
方法
利用 2007-2018 年全国健康和营养调查（NHANES）的数据。采用多变量逻辑回归模型和限制三次样条模型来研究总钙、镁、锌和铜摄入量与糖尿病视网膜病变之间的关联。
结果
共纳入 3794 名年龄在 40 岁或以上的成年人。钙、镁、锌和铜摄入量较高的四分位数与 DR 的发生呈负相关，多变量校正后的 OR（95%CI）分别为 0.57（0.38-0.86）、0.48（0.32-0.73）、0.58（0.39-0.88）和 0.48（0.30-0.77）。钙、镁、锌、铜摄入量与 DR 风险之间存在 U 形剂量反应关系。
结论
美国糖尿病成年人中，总钙、镁、锌和铜的摄入量较高与 DR 风险呈负相关。
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