Department of Emergency Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Emergency and Difficult Diseases Institute of Central South University, Changsha, Hunan 410011, China.
Department of Kidney Transplantation, Center of Organ Transplantation, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
J Trace Elem Med Biol. 2024 May;83:127416. doi: 10.1016/j.jtemb.2024.127416. Epub 2024 Feb 21.
The relationship between dietary metal intake and mortality risk is controversial, and we investigated the relationship between intake of five metals (iron, copper, selenium, zinc, and magnesium) and all-cause, cardiovascular mortality in the total population, gender subgroups, and age subgroups.
17,207 participants from the National Health and Nutrition Examination Survey (NHANES) database from 2009 to 2016 were included in this study. Kaplan-Meier survival curves, multivariate Cox proportional hazards models, and restrictive cubic spline (RCS) curves were used to explore the association between metal intake and all-cause, cardiovascular mortality.
In this study, the average dietary metal intake of men and older people was lower than that of women and younger people. The RCS curves found in the whole population that all-cause mortality was negative linearly associated with copper intakes, L-shaped with zinc and magnesium intakes. Further subgroup analyses of copper, zinc, and magnesium by age and gender revealed that only magnesium showed statistically significant differences in the age subgroups. In the 20-40 population, there was a non-linear increasing trend in magnesium intake and all-cause mortality, whereas there was a non-linear decreasing trend in the > 60 population.
The relationship between metal intake and mortality is more than a simple linear correlation, and differences in age can affect this correlation. In metal exposure studies, different populations can be studied to better determine the effect of metal exposure on mortality.
The dataset used for statistical analysis in this study is available on the NHANES website: https://www.cdc.gov/nchs/nhanes/index.htm.
饮食中金属摄入与死亡风险之间的关系存在争议，我们调查了五种金属（铁、铜、硒、锌和镁）的摄入量与全因、心血管死亡率之间的关系，包括总人群、性别亚组和年龄亚组。
本研究纳入了 2009 年至 2016 年国家健康和营养调查（NHANES）数据库中的 17207 名参与者。使用 Kaplan-Meier 生存曲线、多变量 Cox 比例风险模型和限制性立方样条（RCS）曲线来探讨金属摄入与全因、心血管死亡率之间的关系。
在本研究中，男性和老年人的平均饮食金属摄入量低于女性和年轻人。全人群的 RCS 曲线发现，全因死亡率与铜摄入量呈负线性相关，与锌和镁摄入量呈 L 形相关。进一步按年龄和性别对铜、锌和镁进行亚组分析发现，只有镁在年龄亚组中表现出统计学差异。在 20-40 岁人群中，镁摄入量与全因死亡率呈非线性增加趋势，而在>60 岁人群中呈非线性下降趋势。
金属摄入与死亡率之间的关系不仅仅是简单的线性相关，年龄差异会影响这种相关性。在金属暴露研究中，可以研究不同的人群，以更好地确定金属暴露对死亡率的影响。
本研究统计分析中使用的数据集可在 NHANES 网站上获得：https://www.cdc.gov/nchs/nhanes/index.htm。
