Fujii T, Misumi S, Onoda K, Fukuda H, Ibuki Y
Department of Neurosurgery, Gunma University, School of Medicine, Maebashi, Japan.
Surg Neurol. 1987 Nov;28(5):390-4. doi: 10.1016/0090-3019(87)90064-4.
Three women with pituitary enlargements associated with preexisting target organ failures are reported. Two pituitary enlargements owing to primary hypothyroidism and one to primary hypogonadism were shown to be regressed on computed tomography after the replacement therapy. Clinically and pathologically, the differentiation of a pituitary hyperplasia from a pituitary adenoma is often very difficult. Moreover, the treatments for these conditions are quite different. Adequate medication can diminish a pituitary enlargement because of the feedback mechanism. Existence of the target organ deficiency should always be checked before the management of pituitary tumor.
报告了3例垂体增大并伴有既往靶器官功能衰竭的女性患者。2例因原发性甲状腺功能减退导致的垂体增大和1例因原发性性腺功能减退导致的垂体增大在替代治疗后经计算机断层扫描显示缩小。在临床和病理上，垂体增生与垂体腺瘤的鉴别往往非常困难。此外，这些疾病的治疗方法有很大不同。由于反馈机制，适当的药物治疗可使垂体增大缩小。在处理垂体肿瘤之前，应始终检查是否存在靶器官功能减退。
