State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang, 471934, P. R. China.
Adv Healthc Mater. 2023 Apr;12(11):e2202911. doi: 10.1002/adhm.202202911. Epub 2023 Jan 15.
Organic intercalation of layered nanomaterials is an attractive strategy to fabricate organic/inorganic superlattices for a wide range of promising applications. However, the synthesis of 2D organic/inorganic superlattice nanosheets remains a big challenge. Herein, the preparation of 2D polyaniline/MoO (PANI/MoO ) superlattice nanosheets via intercalation-induced morphological transformation from MoO nanobelts, as efficient Fenton-like reagents for chemodynamic therapy (CDT), is reported. Micrometer-long MoO nanobelts are co-intercalated with Na /H O followed by the guest exchange with aniline monomer for in situ polymerization to obtain PANI/MoO nanosheets. Intriguingly, the PANI intercalation can induce the morphological transformation from long MoO nanobelts to 2D PANI/MoO nanosheets along with the partial reduction of Mo to Mo , and generation of rich oxygen vacancies. More importantly, thanks to the PANI intercalation-induced activation, the PANI/MoO nanosheets exhibit excellent Fenton-like catalytic activity for generation of hydroxyl radical (·OH) by decomposing H O compared with the MoO nanobelts. It is speculated that the good conductivity of PANI can facilitate electron transport during the Fenton-like reaction, thereby enhancing the efficiency of CDT. Thus, the polyvinylpyrrolidone-modified PANI/MoO nanosheets can function as Fenton-like reagents for highly efficient CDT to kill cancer cells and eradicate tumors.
层状纳米材料的有机插层是制备有机/无机超晶格的一种很有吸引力的策略，因为它可以应用于广泛的有前景的领域。然而，二维有机/无机超晶格纳米片的合成仍然是一个巨大的挑战。在此，我们通过形貌转化从 MoO 纳米带制备了二维聚苯胺/ （PANI/MoO ）超晶格纳米片，用作高效的类芬顿试剂用于化学动力学治疗（CDT）。微米级长的 MoO 纳米带与 Na /H O 共插层，然后用苯胺单体进行客体交换进行原位聚合，得到 PANI/MoO 纳米片。有趣的是，PANI 的插层可以诱导从长 MoO 纳米带到二维 PANI/MoO 纳米片的形貌转化，同时 Mo 部分还原为 Mo ，并产生丰富的氧空位。更重要的是，由于 PANI 插层引起的活化，PANI/MoO 纳米片在分解 H O 时表现出优异的类芬顿催化活性，可生成羟基自由基（·OH），而 MoO 纳米带则不行。据推测，PANI 的良好导电性可以在类芬顿反应期间促进电子传递，从而提高 CDT 的效率。因此，经聚乙烯吡咯烷酮修饰的 PANI/MoO 纳米片可用作类芬顿试剂，用于高效的 CDT 以杀死癌细胞并根除肿瘤。
