Shenzhen Key Laboratory of Nanozymes and Translational Cancer Research, Institute of Translational Medicine Department of Otolaryngology Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen, 518035, People's Republic of China.
Graduate Collaborative Training Base of Shenzhen Second People's Hospital, Heng Yang Medical School, University of South China, Hengyang, Hunan, 421001, People's Republic of China.
Int J Nanomedicine. 2024 Jan 24;19:805-824. doi: 10.2147/IJN.S444471. eCollection 2024.
In recent years, metal-containing two-dimensional (2D) nanomaterials, among various 2D nanomaterials have attracted widespread attention because of their unique physical and chemical properties, especially in the fields of biomedical applications. Firstly, the review provides a brief introduction to two types of metal-containing 2D nanomaterials, based on whether metal species take up the major skeleton of the 2D nanomaterials. After this, the synthetical approaches are summarized, focusing on two strategies similar to other 2D nanomaterials, top-down and bottom-up methods. Then, the performance and evaluation of these 2D nanomaterials when applied to cancer therapy are discussed in detail. The specificity of metal-containing 2D nanomaterials in physics and optics makes them capable of killing cancer cells in a variety of ways, such as photodynamic therapy, photothermal therapy, sonodynamic therapy, chemodynamic therapy and so on. Besides, the integrated platform of diagnosis and treatment and the clinical translatability through metal-containing 2D nanomaterials is also introduced in this review. In the summary and perspective section, advanced rational design, challenges and promising clinical contributions to cancer therapy of these emerging metal-containing 2D nanomaterials are discussed.
近年来，含金属的二维（2D）纳米材料在各种 2D 纳米材料中引起了广泛关注，因为它们具有独特的物理和化学性质，特别是在生物医学应用领域。首先，综述简要介绍了两类基于金属物种是否占据 2D 纳米材料主要骨架的含金属 2D 纳米材料。之后，重点介绍了类似于其他 2D 纳米材料的两种策略，自上而下和自下而上的方法，总结了它们的合成方法。然后，详细讨论了这些 2D 纳米材料在癌症治疗中的应用性能和评价。含金属 2D 纳米材料在物理和光学方面的特异性使它们能够通过多种方式杀死癌细胞，如光动力疗法、光热疗法、声动力疗法、化学动力学疗法等。此外，本文还介绍了通过含金属 2D 纳米材料实现诊断和治疗一体化平台以及临床转化的情况。在总结和展望部分，讨论了这些新兴的含金属 2D 纳米材料在癌症治疗方面的先进合理设计、挑战和有希望的临床贡献。
