突尼斯人群样本中的人类白细胞抗原A、B、C和DR抗原。

HLA-A,B,C and DR antigens in a sample of the Tunisian population.

作者信息

Ayed K, Bardi R, Gebuhrer L, Gorgi Y, Betuel H

机构信息

Laboratoire d'Immunologie, Faculté de Médecine de Tunis, Tunisia.

出版信息

Tissue Antigens. 1987 May;29(5):225-31. doi: 10.1111/j.1399-0039.1987.tb01581.x.

DOI:10.1111/j.1399-0039.1987.tb01581.x

PMID:3660397

Abstract

The HLA-A, B and DR phenotypes of 109 unrelated Tunisian individuals have been determined. The HLA-A and B antigen frequencies were compared with data reported for European Caucasoids and various Arab populations. Most similarities in antigen frequencies were seen between Tunisians and Kabyles from North Africa. A high frequency of HLA-A23 and HLA-Bw50 was observed in Tunisians and all Arab populations. A very close similarity in HLA-DR antigen frequencies exists between Tunisians and European Caucasoids. Linkage disequilibria between alleles of HLA loci were examined; many instances of previously reported antigen associations were seen in Tunisians, together with a number of associations which have not been described elsewhere. Aw34B8 and A2DRw14 are suggested as being common haplotypes in Tunisians.

摘要

已确定109名突尼斯无关个体的HLA - A、B和DR表型。将HLA - A和B抗原频率与报道的欧洲白种人和不同阿拉伯人群的数据进行了比较。突尼斯人与来自北非的卡拜尔人之间在抗原频率上有大多数相似之处。在突尼斯人和所有阿拉伯人群中均观察到HLA - A23和HLA - Bw50的高频率。突尼斯人与欧洲白种人在HLA - DR抗原频率上存在非常密切的相似性。对HLA基因座的等位基因之间的连锁不平衡进行了检查；在突尼斯人中发现了许多先前报道的抗原关联实例，以及一些在其他地方未描述的关联。Aw34B8和A2DRw14被认为是突尼斯人中常见的单倍型。