沙特阿拉伯人的人类白细胞抗原多态性

HLA polymorphisms in Saudi Arabs.

作者信息

Ollier W, Doyle P, Alonso A, Awad J, Williams E, Gill D, Welch S, Klouda P, Bacchus R, Festenstein H

出版信息

Tissue Antigens. 1985 Feb;25(2):87-95. doi: 10.1111/j.1399-0039.1985.tb00420.x.

DOI:10.1111/j.1399-0039.1985.tb00420.x

Abstract

The HLA-A, -B, -C, -DR, Bf and GLO phenotypes of 109 unrelated Saudi Arab males have been determined. HLA-A and -B antigen frequencies were compared with data reported for European Caucasoids and various Arab populations. Most similarities in antigen frequencies were seen between Saudi Arab and Iraqi populations. A high frequency of Bw50 was observed in Saudi Arabs. The frequencies of HLA-DR antigens in Saudi Arabs were compared to European Caucasoids. HLA-DR7 was at high frequency in Saudi Arabs. Linkage disequilibria between alleles of HLA loci was examined. Many instances of previously reported antigen associations were seen in Saudi Arabs, together with a number of associations which have not been described elsewhere. HLA-Cw6-Bw50-DR7-BfS0.7 is suggested as being a common haplotype in Saudi Arabs.

摘要

已确定109名无亲缘关系的沙特阿拉伯男性的HLA - A、- B、- C、- DR、Bf和GLO表型。将HLA - A和 - B抗原频率与报道的欧洲白种人和不同阿拉伯人群的数据进行了比较。在沙特阿拉伯人和伊拉克人群之间观察到抗原频率的最大相似性。在沙特阿拉伯人中观察到Bw50的高频率。将沙特阿拉伯人的HLA - DR抗原频率与欧洲白种人进行了比较。HLA - DR7在沙特阿拉伯人中频率较高。检查了HLA基因座等位基因之间的连锁不平衡。在沙特阿拉伯人中发现了许多先前报道的抗原关联实例，以及一些在其他地方未描述过的关联。HLA - Cw6 - Bw50 - DR7 - BfS0.7被认为是沙特阿拉伯人中的一种常见单倍型。