Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Anesthesiology, Sichuan Cancer Hospital and Research Institute, Chengdu, Sichuan, China.
BMJ Open. 2023 Jan 5;13(1):e065304. doi: 10.1136/bmjopen-2022-065304.
An increasing number of elderly patients suffer from hip diseases associated with moderate to severe perioperative pain during the accelerating global ageing process. Optimal analgesia can decrease perioperative complications and facilitate elderly patients' perioperative recovery. Pericapsular nerve group (PENG) block is a relatively new, analgesia adequate and motor-sparing block technique for perioperative pain management of hip diseases. However, the efficacy of PENG block remains unclear as the limited clinical evidence. Then, we will perform a protocol for a systematic review and meta-analysis to identify the efficacy of PENG block for perioperative pain management.
PubMed, Ovid Medline, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure, Chinese BioMedical Literature, Wanfang and VIP databases will be searched from inception to August 2022 to identify randomised controlled trials of elderly patients accepting PENG block for hip diseases. The primary outcome will be the pain intensity after pain management. Secondary outcomes will be quadriceps strength, perioperative rescue analgesia information and perioperative complications. Assessment of heterogeneity will be primarily inspected by forest plots. If there is no indication of funnel plot asymmetry, a random-effects meta-analysis will be performed. The Cochrane risk-of-bias tool, Grading of Recommendations Assessment, Development and Evaluation and trial sequential analysis will be conducted to evaluate the evidence quality and control the random errors. Funnel plots and Egger's regression test will be performed to evaluate publication bias.
Ethical approval was not required for this systematic review protocol. The results will be disseminated through peer-reviewed publications.
CRD42022313895.
在全球老龄化进程加速的背景下，越来越多的老年患者患有与围手术期中度至重度疼痛相关的髋部疾病。最佳的镇痛效果可以降低围手术期并发症，促进老年患者的围手术期康复。囊周神经群（PENG）阻滞是一种新的、镇痛效果充分且能保留运动功能的阻滞技术，可用于髋部疾病的围手术期疼痛管理。然而，由于临床证据有限，PENG 阻滞的疗效尚不清楚。因此，我们将制定一个系统评价和荟萃分析的方案，以确定 PENG 阻滞在髋部疾病围手术期疼痛管理中的疗效。
从建库至 2022 年 8 月，我们将在 PubMed、Ovid Medline、Cochrane 图书馆、Embase、Web of Science、中国知网、中国生物医学文献数据库、万方和维普数据库中搜索接受 PENG 阻滞治疗髋部疾病的老年患者的随机对照试验。主要结局指标为疼痛管理后的疼痛强度。次要结局指标为股四头肌力量、围手术期补救性镇痛信息和围手术期并发症。异质性评估主要通过森林图进行检查。如果没有漏斗图不对称的迹象，将进行随机效应荟萃分析。采用 Cochrane 偏倚风险工具、推荐评估、制定和评价分级和试验序贯分析来评估证据质量并控制随机误差。将进行漏斗图和 Egger 回归检验以评估发表偏倚。
本系统评价方案不需要伦理批准。研究结果将通过同行评审的出版物进行传播。
PROSPERO 注册号：CRD42022313895。
