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多感觉训练改善偏盲。

Ameliorating Hemianopia with Multisensory Training.

机构信息

Departments of Neurobiology and Anatomy

Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157.

出版信息

J Neurosci. 2023 Feb 8;43(6):1018-1026. doi: 10.1523/JNEUROSCI.0962-22.2022. Epub 2023 Jan 5.

Abstract

Hemianopia (unilateral blindness), a common consequence of stroke and trauma to visual cortex, is a debilitating disorder for which there are few treatments. Research in an animal model has suggested that visual-auditory stimulation therapy, which exploits the multisensory architecture of the brain, may be effective in restoring visual sensitivity in hemianopia. It was tested in two male human patients who were hemianopic for at least 8 months following a stroke. The patients were repeatedly exposed to congruent visual-auditory stimuli within their blinded hemifield during 2 h sessions over several weeks. The results were dramatic. Both recovered the ability to detect and describe visual stimuli throughout their formerly blind field within a few weeks. They could also localize these stimuli, identify some of their features, and perceive multiple visual stimuli simultaneously in both fields. These results indicate that the multisensory therapy is a rapid and effective method for restoring visual function in hemianopia. Hemianopia (blindness on one side of space) is widely considered to be a permanent disorder. Here, we show that a simple multisensory training paradigm can ameliorate this disorder in human patients.

摘要

偏盲(单侧失明)是中风和视觉皮层损伤的常见后果,是一种使人衰弱的疾病,几乎没有治疗方法。动物模型的研究表明,利用大脑的多感觉结构的视听刺激疗法可能有效恢复偏盲患者的视觉敏感性。该方法在两名男性中风后至少 8 个月出现偏盲的患者中进行了测试。在数周的时间里,患者在 2 小时的治疗过程中反复接受与其失明视野内一致的视听刺激。结果令人瞩目。两名患者在数周内都恢复了在以前失明的视野中检测和描述视觉刺激的能力。他们还能定位这些刺激物、识别其中一些特征,并在两个视野中同时感知多个视觉刺激。这些结果表明,多感觉疗法是一种快速有效的恢复偏盲患者视觉功能的方法。偏盲(空间一侧的失明)被广泛认为是一种永久性疾病。在这里,我们表明,一个简单的多感觉训练范式可以改善人类患者的这种疾病。

相似文献

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Ameliorating Hemianopia with Multisensory Training.多感觉训练改善偏盲。
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Using superior colliculus principles of multisensory integration to reverse hemianopia.利用上丘的多感觉整合原理来逆转偏盲。
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本文引用的文献

1
Visual instrumental learning in blindsight monkeys.盲视猴子的视觉工具性学习。
Sci Rep. 2021 Jul 20;11(1):14819. doi: 10.1038/s41598-021-94192-7.
2
Neural Mechanism of Blindsight in a Macaque Model.猕猴模型中盲视的神经机制
Neuroscience. 2021 Aug 10;469:138-161. doi: 10.1016/j.neuroscience.2021.06.022. Epub 2021 Jun 19.
5
Rehabilitation of cortically induced visual field loss.皮质诱导的视野缺失的康复。
Curr Opin Neurol. 2021 Feb 1;34(1):67-74. doi: 10.1097/WCO.0000000000000884.
7
Using superior colliculus principles of multisensory integration to reverse hemianopia.利用上丘的多感觉整合原理来逆转偏盲。
Neuropsychologia. 2020 Apr;141:107413. doi: 10.1016/j.neuropsychologia.2020.107413. Epub 2020 Feb 27.
8
Reversing Hemianopia by Multisensory Training Under Anesthesia.麻醉下多感官训练逆转偏盲
Front Syst Neurosci. 2020 Jan 31;14:4. doi: 10.3389/fnsys.2020.00004. eCollection 2020.

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