人体和大鼠组织中的金属硫蛋白、镉、铜和锌含量。

Metallothionein, cadmium, copper and zinc levels of human and rat tissues.

作者信息

Heilmaier H E, Drasch G A, Kretschmer E, Summer K H

机构信息

Institute of Toxicology, Gesellschaft für Strahlen- und Umweltforschung München, Neuherberg, F.R.G.

出版信息

Toxicol Lett. 1987 Oct;38(3):205-11. doi: 10.1016/0378-4274(87)90001-4.

DOI:10.1016/0378-4274(87)90001-4

PMID:3660424

Abstract

Metallothionein (MT), zinc (Zn), copper (Cu) and cadmium (Cd) were determined in 10 tissues (brain, heart, kidney cortex, liver, lung, muscle, pancreas, small intestine, spleen and stomach) from human autopsies (10 male individuals, mean age 43 +/- 9 years, all smokers) and Wistar rats. The mean tissue concentrations of MT in the human samples varied between 3.8 and 495 micrograms/g wet weight in spleen and kidney cortex, respectively. In most tissues human MT levels were high as compared to rats; particularly in liver and kidney cortex human MT levels exceeded those of rats about 25- and 10-fold, respectively. Positive linear relationships were observed between Zn or Cu and MT in human liver and between Cd and MT in human kidney cortex.

摘要

在来自人体尸检（10名男性个体，平均年龄43±9岁，均为吸烟者）和Wistar大鼠的10种组织（脑、心脏、肾皮质、肝脏、肺、肌肉、胰腺、小肠、脾脏和胃）中测定了金属硫蛋白（MT）、锌（Zn）、铜（Cu）和镉（Cd）。人体样本中MT的平均组织浓度在脾脏和肾皮质中分别为3.8至495微克/克湿重。在大多数组织中，人体MT水平高于大鼠；特别是在肝脏和肾皮质中，人体MT水平分别比大鼠高出约25倍和10倍。在人体肝脏中观察到Zn或Cu与MT之间呈正线性关系，在人体肾皮质中观察到Cd与MT之间呈正线性关系。