Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, Jiangsu, 210029, China.
Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, Jiangsu, 210029, China; Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, 215000, China.
Nutr Metab Cardiovasc Dis. 2023 Feb;33(2):350-358. doi: 10.1016/j.numecd.2022.11.014. Epub 2022 Nov 18.
Epidemiological evidence of the association between migraines, severe headaches, and hypertension is contradictory. Hypertension is a critical risk factor for cardiovascular diseases. Migraine is a common neurological disease and a major cause of disability worldwide. Therefore, we aimed to investigate the relationship between migraine, severe headaches, and hypertension among US adults.
Cross-sectional data from 5716 subjects were obtained from the National Health and Nutrition Examination Survey between 1999 and 2004. Weighted logistic regression models investigated the association between migraines, severe headaches, and hypertension. In total, 5716 subjects were enrolled in the present study, of whom 1134 (19.8%) had migraine or severe headaches. Participants with migraine were predominantly younger females and had a higher body mass index (BMI), lower educational level, lower dietary intake of potassium and calcium, lower serum levels of total cholesterol (TC), creatinine, and hemoglobin, as well as a higher estimated glomerular filtration rate (eGFR) (all P < 0.05). After fully adjusting for potential confounders, migraine or severe headaches were positively associated with hypertension (OR 1.25, 95% CI: 1.03-1.53).
Our study found a positive association between migraine, severe headaches, and hypertension. Further studies are needed to verify the causality of this association and elucidate the underlying mechanisms.
偏头痛、严重头痛和高血压之间关联的流行病学证据存在矛盾。高血压是心血管疾病的关键危险因素。偏头痛是一种常见的神经系统疾病，也是全球范围内导致残疾的主要原因之一。因此，我们旨在调查美国成年人中偏头痛、严重头痛和高血压之间的关系。
本研究采用 1999 年至 2004 年期间进行的全国健康和营养调查的 5716 名受试者的横断面数据。使用加权逻辑回归模型来研究偏头痛、严重头痛和高血压之间的关联。本研究共纳入 5716 名受试者，其中 1134 名（19.8%）患有偏头痛或严重头痛。偏头痛患者主要为年轻女性，且具有更高的体重指数（BMI）、更低的受教育程度、更低的钾和钙膳食摄入量、更低的总胆固醇（TC）、肌酐和血红蛋白血清水平，以及更高的估计肾小球滤过率（eGFR）（均 P<0.05）。在充分调整潜在混杂因素后，偏头痛或严重头痛与高血压呈正相关（OR 1.25，95%CI：1.03-1.53）。
我们的研究发现偏头痛、严重头痛和高血压之间存在正相关关系。需要进一步的研究来验证这种关联的因果关系，并阐明潜在的机制。
Zotero 插件