20至49岁人群中人类单纯疱疹病毒与严重头痛或偏头痛之间的关联：一项横断面研究。
Association between human herpes simplex virus and severe headache or migraine among aged 20-49 years: a cross-sectional study.
作者信息
Zheng Tao, Jiang Li, Li Guanglu, Zeng Na, Yu Binyang, Duan Shaojie, Wang Gesheng, Liu Zunjing
机构信息
Beijing University of Chinese Medicine, Beijing, China.
Department of Brain Disease III, Dongfang Hospital Beijing University of Chinese Medicine, Beijing, China.
出版信息
Front Neurol. 2024 Oct 8;15:1476863. doi: 10.3389/fneur.2024.1476863. eCollection 2024.
BACKGROUND AND PURPOSE
Previous studies have shown that human herpes simplex virus (HSV) infection may be associated with the onset of headache or migraine. We aimed to investigate the association between HSV infection and severe headache or migraine.
MATERIALS AND METHODS
The cross-sectional data on 5,730 participants aged 20-49 years were obtained from the 1999-2004 National Health and Nutrition Examination Survey (NHANES). We used weighted logistic regression analysis to assess the association between HSV infection (HSV-1 gG-1 and HSV-2 gG-2) and severe headache or migraine, and performed subgroup analyses.
RESULTS
Our study found that women, higher education, higher body mass index, better family conditions, smoking and alcohol consumption were all associated with severe headaches or migraines. After adjusting for confounding factors such as sex, age, race, and education, HSV-2 (+) was still significantly associated with severe headache or migraine (OR = 1.22, 95%CI:1.03-1.46, = 0.0443). In subgroup analyses, we found that participants with HSV-1 (-) and HSV-2 (+) were also significantly associated with severe headache or migraine (OR = 1.41, 95%CI:1.04-1.91, = 0.0281).
CONCLUSION
HSV-2 gG-2(+) was significantly associated with severe headache or migraine.
背景与目的
既往研究表明，人类单纯疱疹病毒（HSV）感染可能与头痛或偏头痛的发作有关。我们旨在研究HSV感染与严重头痛或偏头痛之间的关联。
材料与方法
横断面数据来自1999 - 2004年美国国家健康与营养检查调查（NHANES），共纳入5730名年龄在20 - 49岁的参与者。我们使用加权逻辑回归分析来评估HSV感染（HSV - 1 gG - 1和HSV - 2 gG - 2）与严重头痛或偏头痛之间的关联，并进行亚组分析。
结果
我们的研究发现，女性、高学历、较高的体重指数、较好的家庭条件、吸烟和饮酒都与严重头痛或偏头痛有关。在调整了性别、年龄、种族和教育等混杂因素后，HSV - 2（+）仍与严重头痛或偏头痛显著相关（OR = 1.22，95%CI：1.03 - 1.46，P = 0.0443）。在亚组分析中，我们发现HSV - 1（-）和HSV - 2（+）的参与者也与严重头痛或偏头痛显著相关（OR = 1.41，95%CI：1.04 - 1.91，P = 0.0281）。
结论
HSV - 2 gG - 2（+）与严重头痛或偏头痛显著相关。
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