普通胆钙化醇与麦角钙化醇对提高泰国女性医护人员血清维生素D水平的疗效比较

Efficacy of plain cholecalciferol versus ergocalciferol in raising serum vitamin D level in Thai female healthcare workers.

作者信息

Amphansap Tanawat, Therdyothin Atiporn, Stitkitti Nitirat, Nitiwarangkul Lertkong, Phiphobmongkol Vajarin

机构信息

Department of Orthopedics, Police General Hospital, 492/1 Rama I Rd, Pathum Wan, Pathum Wan District, Bangkok, 10330, Thailand.

出版信息

Osteoporos Sarcopenia. 2022 Dec;8(4):145-151. doi: 10.1016/j.afos.2022.12.001. Epub 2022 Dec 12.

DOI:10.1016/j.afos.2022.12.001

PMID:36605166

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9805961/

Abstract

OBJECTIVES

To compare the efficacy of cholecalciferol and ergocalciferol in raising 25-hydroxyvitamin D (25(OH)D) level in Thai female healthcare workers.

METHODS

A randomized control trial was conducted in healthy female healthcare workers. Randomization allocated the participants into vitamin D2 group (N = 43), receiving ergocalciferol 20,000 IU weekly and vitamin D3 group (N = 40), receiving cholecalciferol 1000 IU daily for 12 months. Venous blood sample was collected at baseline, 6 and 12 months for serum 25(OH)D, parathyroid hormone and calcium. Compliance was also assessed.

RESULTS

The mean age of the participants was 50.6 ± 9.9 and 50.9 ± 8.4 years in vitamin D2 and D3 groups (P = 0.884). The mean 25(OH)D levels were 16.91 ± 6.07 ng/mL and 17.62 ± 4.39 ng/mL (P = 0.547), respectively. Both groups had significant improvement in 25(OH)D level at 6 months (from 16.91 ± 6.07 to 21.67 ± 5.11 ng/mL and 17.62 ± 4.39 to 26.03 ± 6.59 ng/mL in vitamin D2 and D3 group). Improvement was significantly greater with cholecalciferol (P = 0.018). The level plateaued afterwards in both groups. Only cholecalciferol could increase 25(OH)D in participants without vitamin D deficiency (6.88 ± 4.20 ng/mL increment). Compliance was significantly better in vitamin D2 group (P = 0.025).

CONCLUSIONS

Daily cholecalciferol supplementation resulted in a larger increase in serum 25(OH)D level during the first 6 months comparing to weekly ergocalciferol. While vitamin D3 could increase serum 25(OH)D level in all participants, vitamin D2 could not do so in participants without vitamin D deficiency.

摘要

目的

比较胆钙化醇和麦角钙化醇提高泰国女性医护人员25-羟维生素D（25(OH)D）水平的疗效。

方法

对健康女性医护人员进行一项随机对照试验。随机将参与者分为维生素D2组（N = 43），每周接受20,000 IU麦角钙化醇，以及维生素D3组（N = 40），每天接受1000 IU胆钙化醇，持续12个月。在基线、6个月和12个月时采集静脉血样，检测血清25(OH)D、甲状旁腺激素和钙。同时评估依从性。

结果

维生素D2组和D3组参与者的平均年龄分别为50.6 ± 9.9岁和50.9 ± 8.4岁（P = 0.884）。平均25(OH)D水平分别为16.91 ± 6.07 ng/mL和17.62 ± 4.39 ng/mL（P = 0.547）。两组在6个月时25(OH)D水平均有显著改善（维生素D2组从16.91 ± 6.07 ng/mL升至21.67 ± 5.11 ng/mL，维生素D3组从17.62 ± 4.39 ng/mL升至26.03 ± 6.59 ng/mL）。胆钙化醇组的改善更为显著（P = 0.018）。之后两组水平趋于平稳。只有胆钙化醇能使无维生素D缺乏的参与者的25(OH)D升高（增加6.88 ± 4.20 ng/mL）。维生素D2组的依从性显著更好（P = 0.025）。