Kerckhoff Clinic, ESH Excellence Centre, Bad Nauheim, Germany.
Medical Signal Analysis, AIT Austrian Institute of Technology, Center for Health and Bioresources, Vienna, Austria.
Blood Press Monit. 2023 Feb 1;28(1):52-58. doi: 10.1097/MBP.0000000000000628. Epub 2022 Dec 6.
There isevidence that device-guided slow breathing using biofeedback acutely reduces blood pressure (BP) and pulse wave velocity [i.e. increased pulse arrival time (PAT)].
The objectives of the study presented here were to test whether the results of changes observed in PAT in earlier studies are reproducible over 1 week and how changes in pulse wave velocity/PAT translate into absolute self-measured BP changes.
Patients with a systolic BP 130-160 mmHg or treated essential hypertension (21 females/23 males) were trained to perform unattended device-guided slow breathing exercises for 10 min daily over 5 days. Furthermore, they were skilled to perform self-measurement of BP before and after the breathing exercise using a validated upper-arm device.
Office BP at screening [median (1, 3. Q)] was 137 (132, 142)/83 (79, 87) mmHg. We observed a significant ( P < 0.05) increase in PAT of 5 ms (SD 12.5 ms) on average after 10 min of guided breathing and an additional 1 ms ( P < 0.05, SD 8 ms) during the following 5 min of spontaneous breathing compared to baseline. PAT before the exercise remained constant over 5 days paralleled by constant self-measured BP before the exercise. Device-guided breathing was associated with a significant reduction of self-measured SBP of 5 mmHg ( P < 0.01, SD 8 mmHg). Data furthermore demonstrated that these changes were highly reproducible over 1 week.
Device-guided slow breathing and biofeedback lead to reproducible and favorable changes (increase) in PAT and SBP (decrease).
有证据表明，使用生物反馈的设备引导的缓慢呼吸可在短期内降低血压（BP）和脉搏波速度[即增加脉搏到达时间（PAT）]。
本研究旨在测试在早期研究中观察到的 PAT 变化是否具有可重复性，以及脉搏波速度/PAT 的变化如何转化为自我测量的绝对血压变化。
选择收缩压为 130-160mmHg 的患者或经治疗的原发性高血压患者（21 名女性/23 名男性），每天进行 10 分钟的设备引导的自主缓慢呼吸训练，持续 5 天。此外，他们还接受了使用经过验证的上臂设备进行呼吸运动前后自我测量血压的培训。
筛查时的诊室血压[中位数（1, 3. Q）]为 137（132, 142）/83（79, 87）mmHg。我们观察到，在进行 10 分钟的引导呼吸后，PAT 平均增加了 5ms（SD 12.5ms），而在随后的 5 分钟自主呼吸中又增加了 1ms（P < 0.05，SD 8ms），与基线相比。在运动前，PAT 在 5 天内保持稳定，同时运动前的自我测量血压也保持稳定。设备引导的呼吸与自我测量的 SBP 显著降低 5mmHg（P < 0.01，SD 8mmHg）相关。此外，数据表明这些变化在 1 周内具有高度可重复性。
设备引导的缓慢呼吸和生物反馈可导致 PAT 和 SBP（降低）的可重复和有利变化（增加）。
