Kaur Jaskiran, Gulati Monica, Corrie Leander, Awasthi Ankit, Jha Niraj Kumar, Chellappan Dinesh Kumar, Gupta Gaurav, MacLoughlin Ronan, Oliver Brian G, Dua Kamal, Singh Sachin Kumar
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.
Australian Research Centre in Complementary & Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.
Nanomedicine (Lond). 2022 Oct;17(25):1951-1960. doi: 10.2217/nnm-2022-0260. Epub 2023 Jan 6.
The prevalence of lung diseases is increasing year by year and existing drug therapies only provide symptomatic relief rather than targeting the actual cause. Nucleic acids can be used as an alternative therapeutic approach owing to their potential to reform a homeostatic balance by upregulating protective genes or downregulating damaging genes. However, their inherent properties, such as poor stability, ineffective cellular uptake, negative charge and so on, hinder their clinical utility. Such limitations can be overcome by exploiting the functional chemistry of polymeric micelles (PMs) for site-specific delivery, transfection efficiency and improved stability. With this objective, the present work describes the advancements made in designing nucleic acid-based PMs for treating lung diseases followed by approaches requiring consideration for clinical applications.
肺部疾病的患病率逐年上升，现有的药物治疗仅能缓解症状，而非针对实际病因。核酸因其有可能通过上调保护性基因或下调损伤性基因来恢复体内平衡，可作为一种替代治疗方法。然而，其固有的特性，如稳定性差、细胞摄取效率低、带负电荷等，阻碍了它们的临床应用。利用聚合物胶束（PMs）的功能化学实现靶向递送、提高转染效率和稳定性，可以克服这些限制。基于这一目标，本研究描述了在设计用于治疗肺部疾病的核酸基PMs方面取得的进展，以及临床应用中需要考虑的方法。
