Du Guangxi, Fu Jielin, Zheng Yuanqin, Hu Fuqiang, Shen Xin, Li Baolin, Zhao Xiaohu, Yu Zhipeng
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China.
Org Biomol Chem. 2023 Feb 1;21(5):1021-1026. doi: 10.1039/d2ob02190k.
We investigated the feasibility of creating cyclic azobenzene/azobenzene-based photo-switchable drugs that can fine-tune antibacterial activity against () and () with light dependence. Furthermore, a "light-controlled drug combination" of these obtained drugs could be reversibly controlled to efficiently improve the antibiotic effect so as to reduce the minimum inhibitory concentrations (MICs) with different wavelength light illumination. Importantly, their antimicrobial activity could be easily manipulated by using light in bacterial patterning studies with high spatiotemporal precision, which might allow for localized activation of drugs and provide an alternative solution for practical clinical application in photopharmacology.
我们研究了制备基于环状偶氮苯/偶氮苯的光开关药物的可行性，这类药物可根据光照对针对（）和（）的抗菌活性进行微调。此外，这些所得药物的“光控药物组合”可被可逆控制，以有效提高抗生素效果，从而在不同波长光照下降低最低抑菌浓度（MIC）。重要的是，在细菌模式研究中，利用光可以很容易地以高时空精度操纵它们的抗菌活性，这可能使药物实现局部激活，并为光药理学的实际临床应用提供替代解决方案。
