Han Sangmi, Yeo Joohong, Baek Haju, Lin Shin-Min, Meyer Stacy, Molan Peter
National Academy of Agricultural Science, Agricultural Biology, Suwon, South Korea.
J Asian Nat Prod Res. 2009 Sep;11(9):796-804. doi: 10.1080/10286020903164277.
Since the ancient times, the antibacterial application of honeybee venom (BV) has been practised and persisted. We investigated the antibacterial activity of whole BV and purified melittin against Escherichia coli and Staphylococcus aureus by the minimum inhibitory concentrations (MICs) and the postantibiotic effects (PAEs). The in vitro PAEs of whole BV and isolated melittin were determined using E. coli and S. aureus. The PAEs of whole BV against E. coli and S. aureus were 0.15 h (1 x MIC), 2.4 h (5 x MIC), and 3.45 h (1 x MIC), respectively. The PAEs of melittin against E. coli and S. aureus were 0.1 h (1 x MIC), 3.2 h (5 x MIC), and 4.35 h (1 x MIC), respectively. These results suggest that whole BV and melittin will be developed as a novel antibacterial drug.
自古以来，蜂毒（BV）的抗菌应用就已存在并持续至今。我们通过最低抑菌浓度（MICs）和抗生素后效应（PAEs）研究了全蜂毒和纯化蜂毒肽对大肠杆菌和金黄色葡萄球菌的抗菌活性。使用大肠杆菌和金黄色葡萄球菌测定了全蜂毒和分离的蜂毒肽的体外抗生素后效应。全蜂毒对大肠杆菌和金黄色葡萄球菌的抗生素后效应分别为0.15小时（1倍MIC）、2.4小时（5倍MIC）和3.45小时（1倍MIC）。蜂毒肽对大肠杆菌和金黄色葡萄球菌的抗生素后效应分别为0.1小时（1倍MIC）、3.2小时（5倍MIC）和4.35小时（1倍MIC）。这些结果表明，全蜂毒和蜂毒肽有望开发成为新型抗菌药物。
