[The state of the monooxygenase enzymatic system of the rat liver in hypokinesia].

Activities of amidopyrine N-demethylase, aniline hydroxylase, NADPH, cytochrome c reductase as well as content of cytochromes P-450 and b5 were studied in liver tissue of rats within 1, 3, 7, 10, 20 and 30 days of hypokinesia caused by maintaining of the animals in individual cell-cases. Both the hypokinesia and its combination with adrenalectomy were accompanied by inhibition of microsomal oxidation especially during the later steps of the experiment. At the same time, activity of microsomal enzymes was slightly increased within 1-3 days of the hypokinesia; this effect was not observed after combination of hypokinesia with adrenalectomy. Stress factor appears to be of importance within early periods of hypokinesia, whereas the hypokinesia itself acquires the major role in prolonged deprivation of free motions.