Tayyem Reema F, Ibrahim Mohammed O, Abuhijleh Haya, Alatrash Razan M, Al-Jaberi Tareq, Hushki Ahmad, Albtoush Yazan, Yacoub Shirin, Allehdan Sabika
Department of Nutrition and Food Technology, Faculty of Agriculture, Mu'tah University, Karak.
From the Department of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Pancreas. 2022 Sep 1;51(8):1011-1018. doi: 10.1097/MPA.0000000000002131.
Pancreatic cancer (PC) has been related directly to many risk factors; however, diet is considered one of the most modifiable risk factors. This study is designed to observe the associations between the intake of macromicronutrients and the risk of pancreatic cancer in a Jordanian population.
A case-control study included 100 patients with the incident and histologically confirmed PC and 309 control subjects frequency-matched on age, educational level, occupation, and marital status. Face-to-face interview was used to collect the study's sociodemographic, physical activity, and dietary information. Intakes of macronutrients and micronutrients were assessed by a validated food-frequency questionnaire. Multinomial logistic regression was used to calculate odds ratios and confidence intervals.
The patients reported higher consumption of almost all the macromicronutrients and micronutrients as compared with control subjects. The highest tertile of dietary intake of carbohydrates, sugars, fats, saturated fats, monounsaturated fats, trans fats, cholesterol, and vitamin B3 was positively associated with PC risk (Ptrend < 0.05). However, dietary intakes of polyunsaturated fats, omega-3, and some vitamins and minerals were not associated (Ptrend > 0.05) with the risk of PC.
Our findings support the positive role of proteins, carbohydrates, sugars, fats, saturated fats, monounsaturated fats, trans fats, and cholesterol on pancreatic carcinogenesis.
胰腺癌（PC）与许多危险因素直接相关；然而，饮食被认为是最可改变的危险因素之一。本研究旨在观察约旦人群中大量营养素和微量营养素的摄入量与胰腺癌风险之间的关联。
一项病例对照研究纳入了100例新发且经组织学确诊的胰腺癌患者以及309名在年龄、教育水平、职业和婚姻状况方面频率匹配的对照受试者。通过面对面访谈收集研究的社会人口统计学、身体活动和饮食信息。通过一份经过验证的食物频率问卷评估大量营养素和微量营养素的摄入量。采用多项逻辑回归计算比值比和置信区间。
与对照受试者相比，患者报告几乎所有大量营养素、微量营养素的摄入量都更高。碳水化合物、糖、脂肪、饱和脂肪、单不饱和脂肪、反式脂肪、胆固醇和维生素B3的膳食摄入量最高三分位数与胰腺癌风险呈正相关（趋势P<0.05）。然而，多不饱和脂肪、ω-3以及一些维生素和矿物质的膳食摄入量与胰腺癌风险无关联（趋势P>0.05）。
我们的研究结果支持蛋白质、碳水化合物、糖、脂肪、饱和脂肪、单不饱和脂肪、反式脂肪和胆固醇在胰腺癌发生过程中的积极作用。
