Schnecker K, Rausch W D, Bruck J, Riederer P
Ludwig Boltzmann-Institut für Klinische Neurobiologie, Krankenhaus Wien-Lainz.
Wien Klin Wochenschr. 1987 Aug 28;99(16):572-7.
Serum and cerebrospinal fluid (CSF) from 17 patients less than 3 days after brain infarction (measurement 1) and during recovery 7 +/- 2 days after infarction (measurement 2) were analysed for organic acids (energy metabolites, keto acids and amino acids). Clinical parameters improved by 32% over the period of assessment. Only serum pyruvate levels were elevated at both measurement times. Acute infarction was characterized by significant correspondence of serum and CSF concentrations for pyruvate and alpha-oxo-beta-methyl valeric acid which was lost during the recovery period. Amino acids of the L-system were roughly doubled (phenylalanine 7-fold in the CSF); increased concentrations were recorded for amino acids of the basic transport system, while amino acids of the A-system stayed unchanged (with the exception of alpha-amino butyric acid--20-fold in CSF). Except in the case of taurine, serum and CSF amino acid concentrations remained unchanged between the two measurement times. Mutual dependence of CSF and serum amino acid concentrations, existing initially for glycine, valine, leucine, tyrosine, as well as ornithine, lysine and histidine was lost in the recovery phase. This is interpreted as indication of a normalization of the blood-brain barrier.
对17例脑梗死后3天内（测量1）以及梗死后7±2天恢复期间（测量2）的患者的血清和脑脊液（CSF）进行有机酸（能量代谢物、酮酸和氨基酸）分析。在评估期间临床参数改善了32%。仅血清丙酮酸水平在两个测量时间均升高。急性梗死的特征是血清和脑脊液中丙酮酸和α-氧代-β-甲基戊酸的浓度显著对应，而在恢复期这种对应关系消失。L-系统的氨基酸大致增加了一倍（脑脊液中苯丙氨酸增加了7倍）；碱性转运系统的氨基酸浓度升高，而A-系统的氨基酸保持不变（α-氨基丁酸除外——脑脊液中增加了20倍）。除牛磺酸外，两次测量之间血清和脑脊液氨基酸浓度保持不变。脑脊液和血清氨基酸浓度之间最初存在的甘氨酸、缬氨酸、亮氨酸、酪氨酸以及鸟氨酸、赖氨酸和组氨酸之间的相互依赖性在恢复期消失。这被解释为血脑屏障正常化的迹象。
