Department of Infectious Diseases, Singapore General Hospital, Singapore.
Department of Haematology, Singapore General Hospital, Singapore.
Int J Infect Dis. 2023 Apr;129:236-239. doi: 10.1016/j.ijid.2022.12.040. Epub 2023 Jan 3.
Good syndrome (GS) is a rare acquired immunodeficiency disease characterized by the presence of thymoma with combined B and T cell immunodeficiency in adults. Recurrent bacterial infections, particularly sinopulmonary infections caused by encapsulated bacteria, remain the most common infective presentation of GS; however, relapsing viral infections have also been reported, likely due to impaired T cell-mediated immunity. Relapsing COVID-19 infection, however, has not been previously reported as a manifestation of GS. We present two cases of relapsing COVID-19 infection in patients with GS; in one case, relapsing COVID-19 was the first manifestation of newly diagnosed GS.
Good 综合征（GS）是一种罕见的获得性免疫缺陷病，其特征是成年人存在胸腺瘤伴 B 和 T 细胞联合免疫缺陷。复发性细菌感染，特别是由囊膜细菌引起的肺感染，仍然是 GS 最常见的感染表现；然而，也有报道称复发性病毒感染，可能是由于 T 细胞介导的免疫受损。然而，复发性 COVID-19 感染以前并未被报道为 GS 的表现。我们报告了 2 例 GS 患者的复发性 COVID-19 感染病例；在 1 例病例中，复发性 COVID-19 是新诊断的 GS 的首发表现。
