载脂蛋白E ε4状态与血浆磷酸化tau蛋白181相互作用，影响非痴呆老年人的认知表现。
APOE ε4 status and plasma p-tau181 interact to influence cognitive performance among non-demented older adults.
作者信息
Wang Shanshan, Ke Shaofa, Liu Suzhi, Wang En, Pan Tengwei
机构信息
Department of Neurology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, China.
Department of Neurology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, China.
出版信息
Neurosci Lett. 2023 Feb 6;796:137052. doi: 10.1016/j.neulet.2023.137052. Epub 2023 Jan 3.
OBJECTIVE
In this study, we aimed to investigate the relationships among plasma p-tau181, APOE ε4, and cognitive performance in non-demented elderly individuals.
METHODS
We used individuals (n = 630) with cognitive normal (CN, n = 182) and mild cognitive impairment (MCI, n = 448). Multiple linear regression models were performed to test the effects of APOE ε4 × plasma p-tau181 interaction on MMSE, CDR-SOB, ADAS-cog13, and RAVLT immediate recall. All models adjusted for age, sex, and education.
RESULTS
In total, our study comprised 630 samples including 364 APOE ε4 non-carriers and 266 APOE ε4 carriers. In APOE ε4 carriers, plasma p-tau181 was significantly associated with MMSE (B = -0.04, p = 0.003), ADAS-Cog13 (B [unstandardized coefficient] = 0.21, p < 0.001), CDR-SB (B = 0.02, p = 0.003) and RAVLT immediate recall ((B = -0.17, p = 0.035). After correcting for Aβ status and diagnosis, the interaction between APOE ε4 and plasma p-tau181 was significant or marginally significant associations for RAVLT immediate recall (p = 0.076), MMSE (p = 0.011), CDR (p = 0.008), and ADAS-Cog13 (p < 0.001).
CONCLUSIONS
Our findings suggested that plasma p-tau181 levels predicted cognitive performance among non-demented older adults, but only in the APOE ε4 carriers.
目的
在本研究中，我们旨在调查非痴呆老年人血浆p-tau181、载脂蛋白Eε4（APOE ε4）与认知表现之间的关系。
方法
我们纳入了认知正常（CN，n = 182）和轻度认知障碍（MCI，n = 448）的个体（n = 630）。采用多元线性回归模型来测试APOE ε4×血浆p-tau181相互作用对简易精神状态检查表（MMSE）、临床痴呆评定量表-总和量表（CDR-SOB）、阿尔茨海默病评定量表-认知部分13项（ADAS-cog13）和雷伊听觉词语学习测验即时回忆（RAVLT即时回忆）的影响。所有模型均对年龄、性别和教育程度进行了校正。
结果
我们的研究总共包括630个样本，其中364例为APOE ε4非携带者，266例为APOE ε4携带者。在APOE ε4携带者中，血浆p-tau181与MMSE（B = -0.04，p = 0.003）、ADAS-Cog13（B[未标准化系数]= 0.21，p < 0.001）、CDR-SB（B = 0.02，p = 0.003）和RAVLT即时回忆（B = -0.17，p = 0.035）显著相关。在校正Aβ状态和诊断后，APOE ε与血浆p-tau181之间的相互作用对于RAVLT即时回忆（p = 0.076）、MMSE（p = 0.011）、CDR（p = 0.008）和ADAS-Cog13（p < 0.001）具有显著或边缘显著的关联。
结论
我们的研究结果表明，血浆p-tau181水平可预测非痴呆老年人的认知表现，但仅适用于APOE ε4携带者。
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