Department of Neurology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, China.
Department of Neurology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, China.
Neurosci Lett. 2021 Jun 21;756:135955. doi: 10.1016/j.neulet.2021.135955. Epub 2021 May 9.
We aimed to investigate whether obstructive sleep apnea (OSA) status affects the relationship between cognitive decline and age among non-demented elderly people. A total of 1422 participants (493 normal cognition and 929 amnestic mild cognitive impairment) were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Based on the self-reported medical history of OSA, participants were categorized into two groups (OSA- and OSA +). Multiple linear regression models were performed to assess the effect of the OSA * Age interaction on MMSE, ADAS-cog11 and RAVLT immediate recall in non-demented group and in APOE ε4 carriers/non-carriers adjusting for gender and educational attainment. In the present study, the OSA + group demonstrated significant cognitive decline versus the OSA- group. In addition, in APOE ε4- group, our findings showed a significant OSA * age interaction for ADAS-cog11 and RVALT immediate recall, but not MMSE. No significant interaction was observed in the APOE ε4+ individuals. In conclusion, our findings implicate that OSA status may affect the association of age with cognitive impairment among non-demented older people.
我们旨在探究阻塞性睡眠呼吸暂停（OSA）状态是否会影响认知能力下降与非痴呆老年人年龄之间的关系。我们从阿尔茨海默病神经影像学倡议（ADNI）队列中获得了 1422 名参与者（493 名认知正常和 929 名遗忘型轻度认知障碍）。根据 OSA 的自我报告病史，参与者被分为两组（OSA-和 OSA+）。我们采用多元线性回归模型，评估了 OSA年龄交互作用对非痴呆组和 APOE ε4 携带者/非携带者 MMSE、ADAS-cog11 和 RAVLT 即时回忆的影响，同时调整了性别和教育程度。在本研究中，与 OSA-组相比，OSA+组表现出显著的认知下降。此外，在 APOE ε4-组中，我们的研究结果表明 ADAS-cog11 和 RVALT 即时回忆存在显著的 OSA年龄交互作用，但 MMSE 没有。在 APOE ε4+个体中未观察到显著的交互作用。总之，我们的研究结果表明，OSA 状态可能会影响非痴呆老年人中年龄与认知障碍之间的关联。
