Baker Mary Grace, Sampson Hugh A
Elliot and Roslyn Jaffe Food Allergy Institute, Division of Pediatric Allergy & Immunology, Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY.
Elliot and Roslyn Jaffe Food Allergy Institute, Division of Pediatric Allergy & Immunology, Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY.
J Allergy Clin Immunol. 2023 Jan;151(1):43-46. doi: 10.1016/j.jaci.2022.11.002.
Food protein-induced enterocolitis syndrome (FPIES) was first described in detail in the late 20th century as a non-IgE-mediated food allergy characterized by delayed gastrointestinal symptoms after ingestion of a trigger food. Although the initial case series reported infants reacting to cow's milk- and soy-based formulas, we now recognize that FPIES affects patients across the age spectrum. This brief review highlights our evolving understanding of FPIES with a discussion of triggers, epidemiology, food challenges, and pathophysiology.
食物蛋白诱导的小肠结肠炎综合征（FPIES）在20世纪后期首次得到详细描述，它是一种非IgE介导的食物过敏，其特征为摄入触发食物后出现延迟性胃肠道症状。尽管最初的病例系列报告了婴儿对以牛奶和大豆为基础的配方奶粉产生反应，但我们现在认识到FPIES会影响各个年龄段的患者。这篇简短的综述通过讨论触发因素、流行病学、食物激发试验和病理生理学，突出了我们对FPIES不断演变的认识。
