肌少症与心肌梗死相关性的系统评价和荟萃分析。
A systematic review and meta-analysis of the association between sarcopenia and myocardial infarction.
机构信息
Department of Geriatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
出版信息
BMC Geriatr. 2023 Jan 6;23(1):11. doi: 10.1186/s12877-022-03712-1.
BACKGROUND
Systematic review and meta-analysis of the association between sarcopenia and the development of myocardial infarction.
METHODS
PubMed, Cochrane Library, and Embase were searched for studies on the association between sarcopenia and myocardial infarction from their inception until November 26, 2022. The fixed-effects model was used to calculate the combined risk ratio (RR) of sarcopenia in patients with myocardial infarction. Sensitivity analysis was used to test the robust of the combined result, and funnel plot were used to test publication bias.
RESULTS
Five studies were included finally. There was no significant association between sarcopenia and risk of developing myocardial infarction [RR = 1.01; 95% CI = 0.94, 1.08; P = 0.317]. The sensitivity analysis showed robust of the combined result. The funnel plot showed no significant publication bias.
CONCLUSION
Limited evidence suggests no definitive association between sarcopenia and risk of myocardial infarction.
背景
肌少症与心肌梗死发展之间关联的系统评价和荟萃分析。
方法
从建库起至 2022 年 11 月 26 日，我们在 PubMed、Cochrane 图书馆和 Embase 上检索了肌少症与心肌梗死之间关联的研究。采用固定效应模型计算肌少症患者发生心肌梗死的合并风险比（RR）。采用敏感性分析检验合并结果的稳健性，并采用漏斗图检验发表偏倚。
结果
最终纳入了 5 项研究。肌少症与发生心肌梗死的风险之间无显著关联[RR=1.01；95%CI=0.94，1.08；P=0.317]。敏感性分析显示合并结果稳健。漏斗图显示无显著发表偏倚。
结论
现有证据有限，无法明确肌少症与心肌梗死风险之间存在关联。
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